Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Barnese, K.; Sheng, Y.; Stich, T.A.; Gralla, E.B.; Britt, R.D.; Cabelli, D.E.; Valentine, J.S.
    Investigation of the highly active manganese superoxide dismutase from Saccharomyces cerevisiae (2010), J. Am. Chem. Soc., 132, 12525-12527.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.15.1.1 additional information
-
 additional information rate constants and kinetics compared to other SODs from other species, overview Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 mitochondrial matrix
-
 Saccharomyces cerevisiae 5759
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Mn Mn-SOD Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.15.1.1 2 O2.- + 2 H+ + Saccharomyces cerevisiae
-
 O2 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Saccharomyces cerevisiae
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.15.1.1 additional information
-
 yeast Mn-SOD shows high activity compared to other species' enzymes Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.15.1.1 2 O2.- + 2 H+ +
-
 Saccharomyces cerevisiae O2 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.15.1.1 homotetramer
-
 Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 manganese superoxide dismutase
-
 Saccharomyces cerevisiae
1.15.1.1 MnSOD
-
 Saccharomyces cerevisiae

General Information

EC Number General Information Comment Organism
1.15.1.1 physiological function manganese superoxide dismutase enzymes catalyze superoxide disproportionation by a mechanism that is more complex than those of the other SOD types. In particular the reduction of superoxide can proceed via one of two pathways. One pathway dominates when the O2- concentration is low relative to the enzyme concentration, and the other pathway dominates when the ratio [O2-]/[MnSOD] is high, overview Saccharomyces cerevisiae