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Literature summary extracted from

  • Hollmann, F.; Hofstetter, K.; Habicher, T.; Hauer, B.; Schmid, A.
    Direct electrochemical regeneration of monooxygenase subunits for biocatalytic asymmetric epoxidation (2005), J. Am. Chem. Soc., 127, 6540-6541.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.11 styrene + FADH2 + O2 Pseudomonas sp.
-
 (S)-2-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 styrene + FADH2 + O2 Pseudomonas sp. VLB120
-
 (S)-2-phenyloxirane + FAD + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.11 Pseudomonas sp.
-
-
-
1.14.14.11 Pseudomonas sp. VLB120
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.11 additional information feasibility of direct electrochemical regeneration of a flavin-dependent monooxygenase for catalysis. Driven only by electrical power, optically pure epoxides are synthesized from corresponding vinyl aromatic compounds. The complicated native enzyme system consisting of three enzymes (StyA, StyB, and an NADH regenerating enzyme) and two cofactors (NADH and FAD) is minimized to the oxygenase component and its flavin prosthetic group Pseudomonas sp. ?
-
 ?
1.14.14.11 additional information feasibility of direct electrochemical regeneration of a flavin-dependent monooxygenase for catalysis. Driven only by electrical power, optically pure epoxides are synthesized from corresponding vinyl aromatic compounds. The complicated native enzyme system consisting of three enzymes (StyA, StyB, and an NADH regenerating enzyme) and two cofactors (NADH and FAD) is minimized to the oxygenase component and its flavin prosthetic group Pseudomonas sp. VLB120 ?
-
 ?
1.14.14.11 styrene + FADH2 + O2
-
 Pseudomonas sp. (S)-2-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 styrene + FADH2 + O2 production of (S)-styrene oxide with 98.5% enantiomeric excess. Direct electrochemical regeneration of FADH2 to substitute for the complex native regeneration cycle including StyB and NADH Pseudomonas sp. (S)-2-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 styrene + FADH2 + O2
-
 Pseudomonas sp. VLB120 (S)-2-phenyloxirane + FAD + H2O
-
 ?
1.14.14.11 styrene + FADH2 + O2 production of (S)-styrene oxide with 98.5% enantiomeric excess. Direct electrochemical regeneration of FADH2 to substitute for the complex native regeneration cycle including StyB and NADH Pseudomonas sp. VLB120 (S)-2-phenyloxirane + FAD + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.11 StyA
-
 Pseudomonas sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.11 FADH2 direct electrochemical regeneration of FADH2 to substitute for the complex native regeneration cycle including StyB and NADH Pseudomonas sp.