Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Naz, S.; Siddiqi, R.; Dew, T.P.; Williamson, G.
    Epigallocatechin-3-gallate inhibits lactase but is alleviated by salivary proline-rich proteins (2011), J. Agric. Food Chem., 59, 2734-2738.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.62 epigallocatechin-3-gallate inhibits in vitro hydrolysis of lactose by lactase phlorizin hydrolase Rattus norvegicus
3.2.1.108 epigallocatechin-3-gallate inhibition by epigallocatechin-3-gallate of lactase is alleviated about 1.7fold by proline-rich proteins Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.62 Rattus norvegicus
-
-
-
3.2.1.108 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.62 intestine intestinal brush border enzyme Rattus norvegicus
-
3.2.1.108 small intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.62 lactose + H2O
-
 Rattus norvegicus D-glucose + D-galactose
-
 ?
3.2.1.108 lactose + H2O
-
 Rattus norvegicus D-galactose + D-glucose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.62 lactase phlorizin hydrolase
-
 Rattus norvegicus
3.2.1.62 LPH
-
 Rattus norvegicus
3.2.1.108 lactase phlorizin hydrolase
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.62 0.074
-
 in 1.5 mM sodium phosphate buffer (pH 6.8), at 37°C Rattus norvegicus epigallocatechin-3-gallate
3.2.1.108 0.074
-
 in the absence of proline-rich protein fraction, in 1.5 mM sodium phosphate buffer (pH 6.8), at 37°C Rattus norvegicus epigallocatechin-3-gallate
3.2.1.108 0.126
-
 in the presence of proline-rich protein fraction, in 1.5 mM sodium phosphate buffer (pH 6.8), at 37°C Rattus norvegicus epigallocatechin-3-gallate