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Literature summary extracted from

  • Ueda, K.; Yoshihara, M.; Nakao, M.; Tanaka, T.; Sano, S.; Fukuzawa, K.; Tokumura, A.
    Evaluation of inhibitory actions of flavonols and related substances on lysophospholipase D activity of serum autotaxin by a convenient assay using a chromogenic substrate (2010), J. Agric. Food Chem., 58, 6053-6063.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.39 isoquercitrin
-
Homo sapiens
3.1.4.39 isorhamnetin
-
Homo sapiens
3.1.4.39 isorhamnetin-3-O-glucoside
-
Homo sapiens
3.1.4.39 additional information the low hydrophobicity of an inhibitor is a critical factor in its preference for the binding to a noncatalytic binding site over a catalytic binding site in ATX. Structure-activity relationship of inhibition on lysoPLD activity by polyphenols, overview. Resveratrol, caffeine, L-amino acids, tyrosine, phenylalanine, and 3-(3,4-dihydroxyphenyl)alanine, and phenolic antioxidants (propyl gallate, BHT, BHA), methyl (R)-(þ)-2-(4-hydroxyphenoxy)propionate, 3-(4-hydroxyphenyl)-1-propanol, and 4-(4-hydroxyphenyl)-2-butanone are inactive. Also inactive are flavonols kaempferol, tamarixetin, flavones luteolin, apigenin, chrysin, flavanols (+)-catechin, (-)-epicatechin, isoflavones daidzein, genistein; the low hydrophobicity of an inhibitor is a critical factor in its preference for the binding to a noncatalytic binding site over a catalytic binding site in ATX. Structure-activity relationship of inhibition on lysoPLD activity by polyphenols, overview. Resveratrol, caffeine, L-amino acids, tyrosine, phenylalanine, and 3-(3,4-dihydroxyphenyl)alanine, and phenolic antioxidants (propyl gallate, BHT, BHA), methyl (R)-(+)-2-(4-hydroxyphenoxy)propionate, 3-(4-hydroxyphenyl)-1-propanol, and 4-(4-hydroxyphenyl)-2-butanone are inactive. Also inactive are flavonols kaempferol, tamarixetin, flavones luteolin, apigenin, chrysin, flavanols (+)-catechin, (-)-epicatechin, isoflavones daidzein, genistein Homo sapiens
3.1.4.39 myricetin
-
Homo sapiens
3.1.4.39 quercetagetin
-
Homo sapiens
3.1.4.39 robinetin
-
Homo sapiens
3.1.4.39 rutin
-
Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 additional information assay development devised to quantify 4-nitrophenol from hydrolysis of chromogenic substrate by serum lysoPLD without tedious lipid extraction procedures Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 ATX
-
Homo sapiens
3.1.4.39 autotaxin
-
Homo sapiens
3.1.4.39 lysophospholipase D
-
Homo sapiens
3.1.4.39 lysoPLD
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.39 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.39 8
-
assay at Homo sapiens