EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.1.7 | expressed in a recombinant baculovirus expression system | Blattella germanica |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.7 | 2,2-dichlorovinyl dimethyl phosphate | - |
Blattella germanica | |
3.1.1.7 | BW284c51 | - |
Blattella germanica | |
3.1.1.7 | Carbaryl | - |
Blattella germanica | |
3.1.1.7 | eserine | - |
Blattella germanica | |
3.1.1.7 | additional information | not inhibited by iso-OMPA | Blattella germanica | |
3.1.1.7 | paraoxon | - |
Blattella germanica | |
3.1.1.7 | propoxur | - |
Blattella germanica |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.7 | 0.041 | - |
butyrylthiocholine iodide | recombinant enzyme AChE2, pH not specified in the publication, 30°C | Blattella germanica | |
3.1.1.7 | 0.067 | - |
acetylthiocholine iodide | recombinant enzyme AChE2, pH not specified in the publication, 30°C | Blattella germanica | |
3.1.1.7 | 0.111 | - |
acetylthiocholine iodide | recombinant enzyme AChE1, pH not specified in the publication, 30°C | Blattella germanica | |
3.1.1.7 | 0.182 | - |
butyrylthiocholine iodide | recombinant enzyme AChE1, pH not specified in the publication, 30°C | Blattella germanica |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
3.1.1.7 | 73000 | - |
2 * 73000, isoform AChE2, SDS-PAGE | Blattella germanica |
3.1.1.7 | 80000 | - |
2 * 80000, isoform AChE1, SDS-PAGE | Blattella germanica |
3.1.1.7 | 146000 | - |
isoform AChE2, nonreducing PAGE | Blattella germanica |
3.1.1.7 | 160000 | - |
isoform AChE1, nonreducing PAGE | Blattella germanica |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.7 | Blattella germanica | - |
German cockroach | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.1.1.7 | glycoprotein | most fractions of isoform AChE1 have a glycophosphatidylinositol anchor, but a small fraction comprises a collagen-like tail. Isoform AChE2 has a collagen-glycophosphatidylinositoI-fused tail | Blattella germanica |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.1.7 | abdomen | - |
Blattella germanica | - |
3.1.1.7 | ganglion | highest AChE1 activity | Blattella germanica | - |
3.1.1.7 | gut | - |
Blattella germanica | - |
3.1.1.7 | head | - |
Blattella germanica | - |
3.1.1.7 | leg | - |
Blattella germanica | - |
3.1.1.7 | thorax | - |
Blattella germanica | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.7 | acetylthiocholine iodide + H2O | - |
Blattella germanica | thiocholine iodide + acetate | - |
? | |
3.1.1.7 | butyrylthiocholine iodide + H2O | - |
Blattella germanica | thiocholine iodide + butyrate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.1.1.7 | homodimer | 2 * 73000, isoform AChE2, SDS-PAGE | Blattella germanica |
3.1.1.7 | homodimer | 2 * 80000, isoform AChE1, SDS-PAGE | Blattella germanica |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.7 | acetylcholinesterase 1 | - |
Blattella germanica |
3.1.1.7 | acetylcholinesterase 2 | - |
Blattella germanica |
3.1.1.7 | AChE | - |
Blattella germanica |
3.1.1.7 | AChE1 | isoform | Blattella germanica |
3.1.1.7 | AChE2 | isoform | Blattella germanica |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.1.1.7 | 0.000298 | - |
recombinant enzyme AChE2, pH not specified in the publication, 30°C | Blattella germanica | eserine | |
3.1.1.7 | 0.000368 | - |
recombinant enzyme AChE2, pH not specified in the publication, 30°C | Blattella germanica | BW284c51 | |
3.1.1.7 | 0.000441 | - |
recombinant enzyme AChE1, pH not specified in the publication, 30°C | Blattella germanica | BW284c51 | |
3.1.1.7 | 0.00133 | - |
recombinant enzyme AChE1, pH not specified in the publication, 30°C | Blattella germanica | paraoxon | |
3.1.1.7 | 0.00201 | - |
recombinant enzyme AChE1, pH not specified in the publication, 30°C | Blattella germanica | eserine | |
3.1.1.7 | 0.00335 | - |
recombinant enzyme AChE2, pH not specified in the publication, 30°C | Blattella germanica | 2,2-dichlorovinyl dimethyl phosphate | |
3.1.1.7 | 0.00447 | - |
recombinant enzyme AChE2, pH not specified in the publication, 30°C | Blattella germanica | paraoxon | |
3.1.1.7 | 0.00755 | - |
recombinant enzyme AChE1, pH not specified in the publication, 30°C | Blattella germanica | propoxur | |
3.1.1.7 | 0.00799 | - |
recombinant enzyme AChE2, pH not specified in the publication, 30°C | Blattella germanica | propoxur | |
3.1.1.7 | 0.0135 | - |
recombinant enzyme AChE2, pH not specified in the publication, 30°C | Blattella germanica | Carbaryl | |
3.1.1.7 | 0.0861 | - |
recombinant enzyme AChE1, pH not specified in the publication, 30°C | Blattella germanica | 2,2-dichlorovinyl dimethyl phosphate | |
3.1.1.7 | 0.36 | - |
recombinant enzyme AChE1, pH not specified in the publication, 30°C | Blattella germanica | Carbaryl |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.1.7 | physiological function | isoform AChE1 plays a major role in postsynaptic transmission | Blattella germanica |