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Literature summary extracted from

  • Akatsu, C.; Mizumoto, S.; Kaneiwa, T.; Maccarana, M.; Malmstroem, A.; Yamada, S.; Sugahara, K.
    Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain (2011), Glycobiology, 21, 565-574.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.19 D-glucuronate Mus musculus
-
 L-iduronate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.1.3.19 Mus musculus Q0VBN2 isoform DS-epi2 (Dse-like)
-
5.1.3.19 Mus musculus Q8BLI4 isoform DS-epi1 (Dse)
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.1.3.19 brain
-
 Mus musculus
-
5.1.3.19 brain isoform DS-epi2 is mostly expressed in the brain during postnatal development Mus musculus
-
5.1.3.19 cerebellum
-
 Mus musculus
-
5.1.3.19 cerebrum
-
 Mus musculus
-
5.1.3.19 hippocampus
-
 Mus musculus
-
5.1.3.19 medulla oblongata
-
 Mus musculus
-
5.1.3.19 midbrain
-
 Mus musculus
-
5.1.3.19 olfactory bulb
-
 Mus musculus
-
5.1.3.19 pons
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.3.19 D-glucuronate
-
 Mus musculus L-iduronate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.1.3.19 dermatan sulfate epimerase 1
-
 Mus musculus
5.1.3.19 dermatan sulfate epimerase 2
-
 Mus musculus
5.1.3.19 DS epimerase 1
-
 Mus musculus
5.1.3.19 DS epimerase 2
-
 Mus musculus
5.1.3.19 DS-epi1 isoform Mus musculus
5.1.3.19 DS-epi2 isoform Mus musculus

General Information

EC Number General Information Comment Organism
5.1.3.19 physiological function isoform DS-epi2 plays key roles in the epimerization of chondroitin sulfate and dermatan sulfate during its biosynthesis. The L-iduronate-containing structures in the developing brain are mainly produced by the actions of isoform DS-epi2 and play crucial roles in postnatal development Mus musculus