Literature summary extracted from

Sakaki, T.; Kagawa, N.; Yamamoto, K.; Inouye, K.
Metabolism of vitamin D3 by cytochromes P450 (2005), Front. Biosci., 10, 119-134.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
1.14.15.16	expressed in Escherichia coli	Homo sapiens
1.14.15.16	expressed in Escherichia coli	Rattus norvegicus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.15.16	Homo sapiens	-	-	-
1.14.15.16	Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.15.16	1alpha,25-dihydroxyvitamin D3 + NADPH + H+ + O2	-	Rattus norvegicus	calcitroic acid + NADP+ + ?	-	?
1.14.15.16	25-hydroxyvitamin D3 + NADPH + H+ + O2	C-23 hydroxylation	Homo sapiens	1alpha,25-dihydroxyvitamin D3-26,23-lactone + NADP+ + H2O	-	?
1.14.15.16	25-hydroxyvitamin D3 + NADPH + H+ + O2	C-24 hydroxylation	Homo sapiens	24R,25-dihydroxyvitamin D3 + NADP+ + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.15.16	1alpha,25-dihydroxyvitamin D3 24-hydroxylase	-	Homo sapiens
1.14.15.16	1alpha,25-dihydroxyvitamin D3 24-hydroxylase	-	Rattus norvegicus
1.14.15.16	CYP24A1	-	Homo sapiens
1.14.15.16	CYP24A1	-	Rattus norvegicus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.15.16	NADPH	-	Homo sapiens
1.14.15.16	NADPH	-	Rattus norvegicus

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Release 2023.1 (January 2023)