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Literature summary extracted from

  • Inarrea, P.; Casanova, A.; Alava, M.A.; Iturralde, M.; Cadenas, E.
    Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450 (2011), Free Radic. Biol. Med., 50, 1575-1581.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.15.1.1 dihydrotestosterone
-
Rattus norvegicus
1.15.1.1 estradiol
-
Rattus norvegicus
1.15.1.1 Melatonin
-
Rattus norvegicus
1.15.1.1 additional information activation of intermembrane space SOD1 upon oxidation of critical thiols. Melatonin, testosterone, dihydrotestosterone, estradiol, and vitamin D induce activation of SOD1 in mitochondria. Enzyme activation is not affected by furafylline, a selective inhibitor of the P450 1A2 isoform, but is inhibited by omeprazole and ketoconazole Rattus norvegicus
1.15.1.1 testosterone
-
Rattus norvegicus
1.15.1.1 vitamin D
-
Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.15.1.1 amiodarone
-
Rattus norvegicus
1.15.1.1 amitriptyline
-
Rattus norvegicus
1.15.1.1 ketoconazole
-
Rattus norvegicus
1.15.1.1 Mg2+
-
Rattus norvegicus
1.15.1.1 additional information melatonin, testosterone, dihydrotestosterone, estradiol, and vitamin D induce activation of SOD1 in mitochondria. Enzyme activation is not affected by furafylline, a selective inhibitor of the P450 1A2 isoform, but is inhibited by omeprazole and ketoconazole, and by tiron, a superoxide radical specific scavenger Rattus norvegicus
1.15.1.1 Omeprazole
-
Rattus norvegicus
1.15.1.1 Tiron
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.15.1.1 mitochondrial intermembrane space
-
Rattus norvegicus 5758
-
1.15.1.1 additional information subcellular localization study of SOD1, overview Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.15.1.1 Cu2+ a CuZn-superoxide dismutase Rattus norvegicus
1.15.1.1 Zn2+ a CuZn-superoxide dismutase Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.15.1.1 Rattus norvegicus
-
male rats
-
1.15.1.1 Rattus norvegicus Wistar
-
male rats
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.15.1.1 native enzyme from mitochondrial intermembrane space of livber microsomes Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.15.1.1 liver
-
Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
1.15.1.1 Cu,Zn-superoxide dismutase
-
Rattus norvegicus
1.15.1.1 SOD1
-
Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.15.1.1 physiological function expression and activity of the mitochondrial P450 system along with substrate availability may contribute to mitochondrial function regulation via activation of IMS SOD1. Activation of intermembrane space SOD1 after incubation of rat liver intact mitochondria with P450 substrates significantly prevents the loss of aconitase activity in the mitochondrial matrix, general mechanism for the SOD1 activation mediated by P450 enzymes, overview Rattus norvegicus