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Literature summary extracted from

  • Huang, J.; Wang, S.; Zhu, M.; Chen, J.; Zhu, X.
    Effects of genistein, apigenin, quercetin, rutin and astilbin on serum uric acid levels and xanthine oxidase activities in normal and hyperuricemic mice (2011), Food Chem. Toxicol., 49, 1943-1947.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.17.3.2 apigenin increases liver xanthine oxidase activities significantly, but has no effect on serum xanthine oxidase activities Mus musculus
1.17.3.2 astilbin significantly increases serum xanthine oxidase activities, and decreases liver xanthine oxidase activities significantly Mus musculus
1.17.3.2 quercetin significantly increases serum xanthine oxidase activities, and decreases liver xanthine oxidase activities significantly Mus musculus
1.17.3.2 rutin significantly increases serum xanthine oxidase activities Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 allopurinol decreasesserum xanthine oxidase activity but increases liver xanthine oxidase activity significantly Mus musculus
1.17.3.2 additional information inhibition of xanthine oxidase by thiosemicarbazones, hydrazones and dithiocarbazates derived from hydroxy-substituted benzaldehydes, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.3.2 extracellular
-
Mus musculus
-
-
1.17.3.2 intracellular
-
Mus musculus 5622
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 xanthine + H2O + O2 Mus musculus
-
urate + H2O2
-
?
1.17.3.2 xanthine + H2O + O2 Mus musculus BALB/c
-
urate + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Mus musculus
-
male mice
-
1.17.3.2 Mus musculus BALB/c
-
male mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 liver
-
Mus musculus
-
1.17.3.2 serum
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 xanthine + H2O + O2
-
Mus musculus urate + H2O2
-
?
1.17.3.2 xanthine + H2O + O2
-
Mus musculus BALB/c urate + H2O2
-
?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.3.2 37
-
assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 7.5
-
assay at Mus musculus

General Information

EC Number General Information Comment Organism
1.17.3.2 additional information serum xanthine oxidase activity is correlated with serum uric acid levels, while no correlation is observed for liver xanthine oxidase activity. The serum uric acid levels in mice treated with the flavonoids genistein, apigenin, quercetin, rutin and astilbin are higher than control levels. No statistically significant difference in serum and liver xanthine oxidase activities between normal control mice and hyperuricemic mice Mus musculus