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Literature summary extracted from

  • Sawai, S.; Uchiyama, H.; Mizuno, S.; Aoki, T.; Akashi, T.; Ayabe, S.; Takahashi, T.
    Molecular characterization of an oxidosqualene cyclase that yields shionone, a unique tetracyclic triterpene ketone of Aster tataricus (2011), FEBS Lett., 585, 1031-1036.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.4.99.46 expressed in lanosterol synthase-deficient yeast Aster tataricus
5.4.99.46 expressed in Saccharomyces cerevisiae strain GIL77 (lanosterol synthase-deficient strain) Aster tataricus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.4.99.39 (S)-2,3-oxidosqualene Aster tataricus
-
 beta-amyrin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.39 Aster tataricus
-
-
-
5.4.99.46 Aster tataricus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.39 flower
-
 Aster tataricus
-
5.4.99.39 leaf
-
 Aster tataricus
-
5.4.99.39 leaf of root and leaf of stem Aster tataricus
-
5.4.99.39 radical leaf
-
 Aster tataricus
-
5.4.99.39 rhizome
-
 Aster tataricus
-
5.4.99.39 root
-
 Aster tataricus
-
5.4.99.39 stem
-
 Aster tataricus
-
5.4.99.39 stolon
-
 Aster tataricus
-
5.4.99.46 flower
-
 Aster tataricus
-
5.4.99.46 flower high expression Aster tataricus
-
5.4.99.46 leaf
-
 Aster tataricus
-
5.4.99.46 leaf high expression Aster tataricus
-
5.4.99.46 radical leaf
-
 Aster tataricus
-
5.4.99.46 rhizome
-
 Aster tataricus
-
5.4.99.46 root
-
 Aster tataricus
-
5.4.99.46 stem
-
 Aster tataricus
-
5.4.99.46 stem high expression Aster tataricus
-
5.4.99.46 stolon
-
 Aster tataricus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.39 (S)-2,3-oxidosqualene
-
 Aster tataricus beta-amyrin
-
 ?
5.4.99.46 (3S)-2,3-epoxy-2,3-dihydrosqualene
-
 Aster tataricus shionone + beta-amyrin + friedelin + dammara-20,24-dienol + 4-epishionone the ratio of the products is roughly estimated as shionone:beta-amyrin:friedelin:dammara-20,24-dienol:4-epishionone = 90%:2%:2%:1.5%:1.5% ?
5.4.99.46 oxidosqualene
-
 Aster tataricus shionone the cyclase yields ca. 90% shionone and small amounts of beta-amyrin, friedelin, dammara-20,24-dienol, and 4-epishionone ?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.39 bAS
-
 Aster tataricus
5.4.99.39 BAS-like 2
-
 Aster tataricus
5.4.99.46 OSC
-
 Aster tataricus
5.4.99.46 Oxidosqualene cyclase
-
 Aster tataricus
5.4.99.46 shionone synthase
-
 Aster tataricus
5.4.99.46 SHS
-
 Aster tataricus