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Literature summary extracted from

  • Dickerhof, N.; Kleffmann, T.; Jack, R.; McCormick, S.
    Bacitracin inhibits the reductive activity of protein disulfide isomerase by disulfide bond formation with free cysteines in the substrate-binding domain (2011), FEBS J., 278, 2034-2043.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.4.1 bacitracin commercial bacitracin consists of 65% bacitracin A and B Bos taurus
5.3.4.1 bacitracin A
-
 Bos taurus
5.3.4.1 bacitracin B
-
 Bos taurus
5.3.4.1 bacitracin F
-
 Bos taurus
5.3.4.1 bacitracin H
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.4.1 endoplasmic reticulum
-
 Bos taurus 5783
-

Organism

EC Number Organism UniProt Comment Textmining
5.3.4.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.4.1 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.4.1 insulin
-
 Bos taurus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.4.1 PDI
-
 Bos taurus
5.3.4.1 protein disulfide isomerase
-
 Bos taurus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.3.4.1 0.02
-
 in 100 mM potassium phosphate and 1 mm EDTA (pH 7.4), at 22°C Bos taurus bacitracin F
5.3.4.1 0.04
-
 in 100 mM potassium phosphate and 1 mm EDTA (pH 7.4), at 22°C Bos taurus bacitracin H
5.3.4.1 0.07
-
 commercial bacitracin, in 100 mM potassium phosphate and 1 mm EDTA (pH 7.4), at 22°C Bos taurus bacitracin
5.3.4.1 0.59
-
 in 100 mM potassium phosphate and 1 mm EDTA (pH 7.4), at 22°C Bos taurus bacitracin A
5.3.4.1 1.05
-
 in 100 mM potassium phosphate and 1 mm EDTA (pH 7.4), at 22°C Bos taurus bacitracin B