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Literature summary extracted from

  • Barbieri, S.S.; Amadio, P.; Gianellini, S.; Zacchi, E.; Weksler, B.B.; Tremoli, E.
    Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase (2011), FASEB J., 25, 3731-3740.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 cardiac endothelial cell
-
 Mus musculus
-
5.3.99.3 cardiac endothelium
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 Prostaglandin H2
-
 Mus musculus Prostaglandin E2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 microsomal prostaglandin E synthase-1
-
 Mus musculus
5.3.99.3 mPGES-1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
5.3.99.3 glutathione
-
 Mus musculus

Expression

EC Number Organism Comment Expression
5.3.99.3 Mus musculus inhibition of NADPH-oxidase negatively modulates mPGES-1 expression induced by tobacco smoke/interleukin-1beta. The activation of mPGES-1 is negatively regulated by prostaglandin I2 down
5.3.99.3 Mus musculus tobacco smoke (EC50 about 5 puffs/l) interacting with IL-1beta (0.002 mg/l) upregulates PGE2 production and mPGES-1 expression, reaching a plateau at 4-6 h up