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Literature summary extracted from
- A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase (2011), FASEB J., 25, 2109-2122.
General Stability
| EC Number | General Stability | Organism |
|---|---|---|
| 4.1.1.22 | HDC is a short-lived enzyme with a half-life of 1-2 h | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.22 | (-)-epigallocatechin 3-gallate | - |
Homo sapiens |  |
| 4.1.1.22 | alpha-Fluoromethylhistidine | - |
Homo sapiens | |
| 4.1.1.22 | L-His-L-Phe | - |
Homo sapiens | |
| 4.1.1.22 | additional information | 1-metylhistidine, L-phenylalanine, L-tryptophan, tert-butyloxycarbonyl-modified ornithine, and tert-butyloxycarbonyl-modified alpha,gamma-diaminobutyric acid do not inhibit human HDC in mast cells and cell extracts significantly | Homo sapiens | |
| 4.1.1.22 | N-pyridoxyl-L-histidine methyl ester | 60% inhibition at 0.2 mM | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.22 | L-histidine | Homo sapiens | - |
histamine + CO2 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.1.1.22 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.1.1.22 | mast cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.1.1.22 | L-histidine | - |
Homo sapiens | histamine + CO2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.1.1.22 | dimer | - |
Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.1.1.22 | HDC | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.1.1.22 | pyridoxal 5'-phosphate | - |
Homo sapiens | |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 4.1.1.22 | Homo sapiens | 12-O-tetradecanoylphorbol-13-acetate induces HDC in mast cells | up |
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Release 2023.1 (January 2023)
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