Literature summary extracted from
Esser, J.; Gehrmann, U.; Salvado, M.D.; Wetterholm, A.; Haeggstroem, J.Z.; Samuelsson, B.; Gabrielsson, S.; Scheynius, A.; Radmark, O.
Zymosan suppresses leukotriene C4 synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors (2011), FASEB J., 25, 1417-1427.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
4.4.1.20 |
leukotriene A4 |
presence of leukotriene A4 results in 20fold increased LTC4S activity during differentiation of monocytic Mono Mac 6 cells, which is reduced by 80% in the presence of zymosan |
Homo sapiens |
|
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
4.4.1.20 |
zymosan |
increase in LTC4S activity during differentiation of monocytic Mono Mac 6 cells by presence of leukotriene A4 is reduced by 80% in the presence of zymosan. Treatment with Zymosan for 48 h similarly attenuates LTC4S activity of primary human monocyte-derived macrophages and dendritic cells |
Homo sapiens |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
4.4.1.20 |
Homo sapiens |
- |
- |
- |
Posttranslational Modification
EC Number |
Posttranslational Modification |
Comment |
Organism |
---|
4.4.1.20 |
phosphoprotein |
phosphoregulation of LTC4S, as increased activity during MM6 cell differentiation correlates with reduced phosphorylation of 70-kDa ribosomal protein S6 kinase, which can phosphorylate purified LTC4S. The ribosomal protein S6 kinase inhibitor rapamycin at 20 nM doubles LTC4S activity of undifferentiated MM6 cells, and protein kinase A and C inhibitors H-89, CGP-53353, and staurosporine reverse the zymosan-induced suppression of LTC4S activity |
Homo sapiens |
Source Tissue
EC Number |
Source Tissue |
Comment |
Organism |
Textmining |
---|
4.4.1.20 |
Mono-Mac-6 cell |
monocytic Mono Mac 6 cell |
Homo sapiens |
- |