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Literature summary extracted from

  • Esser, J.; Gehrmann, U.; Salvado, M.D.; Wetterholm, A.; Haeggstroem, J.Z.; Samuelsson, B.; Gabrielsson, S.; Scheynius, A.; Radmark, O.
    Zymosan suppresses leukotriene C4 synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors (2011), FASEB J., 25, 1417-1427.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.4.1.20 leukotriene A4 presence of leukotriene A4 results in 20fold increased LTC4S activity during differentiation of monocytic Mono Mac 6 cells, which is reduced by 80% in the presence of zymosan Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.20 zymosan increase in LTC4S activity during differentiation of monocytic Mono Mac 6 cells by presence of leukotriene A4 is reduced by 80% in the presence of zymosan. Treatment with Zymosan for 48 h similarly attenuates LTC4S activity of primary human monocyte-derived macrophages and dendritic cells Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.20 Homo sapiens
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
4.4.1.20 phosphoprotein phosphoregulation of LTC4S, as increased activity during MM6 cell differentiation correlates with reduced phosphorylation of 70-kDa ribosomal protein S6 kinase, which can phosphorylate purified LTC4S. The ribosomal protein S6 kinase inhibitor rapamycin at 20 nM doubles LTC4S activity of undifferentiated MM6 cells, and protein kinase A and C inhibitors H-89, CGP-53353, and staurosporine reverse the zymosan-induced suppression of LTC4S activity Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.20 Mono-Mac-6 cell monocytic Mono Mac 6 cell Homo sapiens
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