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Literature summary extracted from

  • Vargas-Villarreal, J.; Palacios-Corona, R.; Hernandez-Luna, C.; Mata-Cardenas, B.D.; Torres de la Cruz, V.M.; Cortes-Gutierrez, E.I.; Gonzalez-Salazar, F.; Garza-Gonzalez, J.N.; Escobedo-Guajardo, B.L.; Said-Fernandez, S.
    Entamoeba histolytica: soluble and membrane-associated neutral sphingomyelinase-C and other unidentified esterase activity (2010), Exp. Parasitol., 125, 394-399.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 Ca2+
-
 Entamoeba histolytica
3.1.4.12 Hg2+
-
 Entamoeba histolytica
3.1.4.12 Zn2+
-
 Entamoeba histolytica
3.1.4.41 Ca2+
-
 Entamoeba histolytica
3.1.4.41 EDTA
-
 Entamoeba histolytica
3.1.4.41 Hg2+
-
 Entamoeba histolytica
3.1.4.41 phosphatidylinositol-3,5-bisphosphate
-
 Entamoeba histolytica
3.1.4.41 Zn2+
-
 Entamoeba histolytica

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 membrane associated Entamoeba histolytica 16020
-
3.1.4.41 membrane associated, SMase-C activity is detected in soluble and particulate fractions Entamoeba histolytica 16020
-
3.1.4.41 soluble SMase-C activity is detected in soluble and particulate fractions Entamoeba histolytica
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Co2+ required Entamoeba histolytica
3.1.4.12 Mg2+ required Entamoeba histolytica
3.1.4.12 Mn2+ required Entamoeba histolytica
3.1.4.41 Co2+ dependent on divalent cations Entamoeba histolytica
3.1.4.41 Mg2+ dependent on divalent cations Entamoeba histolytica
3.1.4.41 Mn2+ dependent on divalent cations Entamoeba histolytica

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.41 sphingomyelin + H2O Entamoeba histolytica
-
 ceramide 1-phosphate + choline
-
 ?
3.1.4.41 sphingomyelin + H2O Entamoeba histolytica HM1
-
 ceramide 1-phosphate + choline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Entamoeba histolytica
-
-
-
3.1.4.41 Entamoeba histolytica
-
-
-
3.1.4.41 Entamoeba histolytica HM1
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 amoeba
-
 Entamoeba histolytica
-
3.1.4.41 trophozoite
-
 Entamoeba histolytica
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.41 54.3
-
 membrane-associated enzyme, pH 7.5, 36.5°C Entamoeba histolytica
3.1.4.41 84.3
-
 soluble enzyme, pH 7.5, 36.5°C Entamoeba histolytica

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.41 sphingomyelin + H2O
-
 Entamoeba histolytica ceramide 1-phosphate + choline
-
 ?
3.1.4.41 sphingomyelin + H2O
-
 Entamoeba histolytica HM1 ceramide 1-phosphate + choline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 neutral sphingomyelinase-C
-
 Entamoeba histolytica
3.1.4.12 SMase-C
-
 Entamoeba histolytica
3.1.4.41 SMase
-
 Entamoeba histolytica
3.1.4.41 SMase-C
-
 Entamoeba histolytica
3.1.4.41 sphingomyelinase
-
 Entamoeba histolytica

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.41 36.5
-
 assay at Entamoeba histolytica

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 7.5
-
-
 Entamoeba histolytica
3.1.4.41 7.5
-
-
 Entamoeba histolytica

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.4.12 3 10 activity range Entamoeba histolytica
3.1.4.41 3 10 activity range Entamoeba histolytica