BRENDA - Enzyme Database show

delta-Aminolevulinic dehydratase is a proteasome interacting protein

Bardag-Gorce, F.; French, S.W.; Exp. Mol. Pathol. 91, 485-489 (2011)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.24
cytosol
-
Rattus norvegicus
5829
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.2.1.24
280000
-
-
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.24
2 5-aminolevulinate
Rattus norvegicus
-
porphobilinogen + 2 H2O
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
4.2.1.24
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
4.2.1.24
native enzyme by ammonium sulfate fractionation, anion exchange chromatography, and gel filtration
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.24
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
2 5-aminolevulinate
-
714924
Rattus norvegicus
porphobilinogen + 2 H2O
-
-
-
?
Subunits
EC Number
Subunits
Commentary
Organism
4.2.1.24
octamer
-
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
4.2.1.24
cytosol
-
Rattus norvegicus
5829
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
4.2.1.24
280000
-
-
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
4.2.1.24
2 5-aminolevulinate
Rattus norvegicus
-
porphobilinogen + 2 H2O
-
-
?
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
4.2.1.24
native enzyme by ammonium sulfate fractionation, anion exchange chromatography, and gel filtration
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
4.2.1.24
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
4.2.1.24
2 5-aminolevulinate
-
714924
Rattus norvegicus
porphobilinogen + 2 H2O
-
-
-
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
4.2.1.24
octamer
-
Rattus norvegicus
General Information
EC Number
General Information
Commentary
Organism
4.2.1.24
physiological function
delta-aminolevulinate dehydratase is a cytosolic sulfhydryl-containing enzyme that catalyzes the condensation of two molecules of aminolevulinic acid in order to form porphobilinogen, which is the precursor of heme, cytochromes and cobalamines. ALAD plays a role in proteasome S26 activity, which it increases by 75%, overview. The 26S proteasome, a protein complex formed by 32 subunits, performs multiple important proteolytic activities in the cell interacting with the ubiquitination system
Rattus norvegicus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
4.2.1.24
physiological function
delta-aminolevulinate dehydratase is a cytosolic sulfhydryl-containing enzyme that catalyzes the condensation of two molecules of aminolevulinic acid in order to form porphobilinogen, which is the precursor of heme, cytochromes and cobalamines. ALAD plays a role in proteasome S26 activity, which it increases by 75%, overview. The 26S proteasome, a protein complex formed by 32 subunits, performs multiple important proteolytic activities in the cell interacting with the ubiquitination system
Rattus norvegicus