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Literature summary extracted from

  • Kajiwara, D.; Aoyagi, H.; Shigeno, K.; Togawa, M.; Tanaka, K.; Inagaki, N.; Miyoshi, K.
    Role of hematopoietic prostaglandin D synthase in biphasic nasal obstruction in guinea pig model of experimental allergic rhinitis (2011), Eur. J. Pharmacol., 667, 389-395.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.2 N-methoxy-N-methyl-4-(5-benzoylbenzimidazole-2-yl)-3,5-dimethylpyrrole-2-carboxamide TAS-204, specific H-PGDS inhibitor Cavia porcellus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.2 Prostaglandin H2 Cavia porcellus
-
Prostaglandin D2
-
?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.2 Cavia porcellus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.2 nasal mucosa
-
Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.2 Prostaglandin H2
-
Cavia porcellus Prostaglandin D2
-
?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.2 H-PGDS
-
Cavia porcellus
5.3.99.2 Hematopoietic prostaglandin D synthase
-
Cavia porcellus

General Information

EC Number General Information Comment Organism
5.3.99.2 physiological function H-PGDS plays a critical role in the development of allergic rhinitis, especially in the induction of late phase nasal obstruction Cavia porcellus