BRENDA - Enzyme Database show

Estrone sulfatase, a target enzyme in the treatment of hormone-dependent breast cancer

Shah, K.; Cartledge, T.; Ahmed, S.; Drugs Future 35, 729-745 (2010)
No PubMed abstract available

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
3.1.6.2
medicine
estrone sulfatase is a target enzyme in the treatment of hormone-dependent breast cancer
Homo sapiens
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
additional information
design and synthesis of steroidal and nonsteroidal enzyme inhibitors as sulfamate derivatives and nonsulfamate derivatives, overview
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.6.2
membrane
-
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
estrone sulfate + H2O
Homo sapiens
-
estrone + sulfate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.1.6.2
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
breast cancer cell
hormone-dependent
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
714821
Homo sapiens
estrone + sulfate
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
3.1.6.2
medicine
estrone sulfatase is a target enzyme in the treatment of hormone-dependent breast cancer
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.1.6.2
additional information
design and synthesis of steroidal and nonsteroidal enzyme inhibitors as sulfamate derivatives and nonsulfamate derivatives, overview
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
3.1.6.2
membrane
-
Homo sapiens
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.1.6.2
estrone sulfate + H2O
Homo sapiens
-
estrone + sulfate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.1.6.2
breast cancer cell
hormone-dependent
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.1.6.2
estrone sulfate + H2O
-
714821
Homo sapiens
estrone + sulfate
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
3.1.6.2
metabolism
conversion of estrone sulfate to estrone is a non-aromatase-based route to estrone and estradiol in postmenopausal women
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
3.1.6.2
metabolism
conversion of estrone sulfate to estrone is a non-aromatase-based route to estrone and estradiol in postmenopausal women
Homo sapiens