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Literature summary extracted from

  • Shah, K.; Cartledge, T.; Ahmed, S.
    Estrone sulfatase, a target enzyme in the treatment of hormone-dependent breast cancer (2010), Drugs Future, 35, 729-745.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.1.6.2 medicine estrone sulfatase is a target enzyme in the treatment of hormone-dependent breast cancer Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 additional information design and synthesis of steroidal and nonsteroidal enzyme inhibitors as sulfamate derivatives and nonsulfamate derivatives, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.6.2 membrane
-
Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.2 estrone sulfate + H2O Homo sapiens
-
estrone + sulfate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.2 breast cancer cell hormone-dependent Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 estrone sulfate + H2O
-
Homo sapiens estrone + sulfate
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.6.2 estrone sulfatase
-
Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.6.2 metabolism conversion of estrone sulfate to estrone is a non-aromatase-based route to estrone and estradiol in postmenopausal women Homo sapiens