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Literature summary extracted from

  • Rozengart, E.; Basova, N.
    Activatory effect of substrates on the cholinesterase catalysis (2010), Dokl. Biochem. Biophys., 430, 7-10.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.8 2,6-dichlorophenolindophenyl acetate exhibits an activatory effect at acid pH values Equus caballus
3.1.1.8 indophenyl acetate exhibits an activatory effect at acid pH values Equus caballus
3.1.1.8 additional information at pH 5.5, phenylacetate exhibits no activatory effect within a broad concentration range (0.5-100 mM) Equus caballus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.8 acetylcholine + H2O Equus caballus
-
 choline + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Equus caballus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 serum
-
 Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 2,6-dichlorophenolindophenyl acetate + H2O
-
 Equus caballus ?
-
 ?
3.1.1.8 acetylcholine + H2O
-
 Equus caballus choline + acetate
-
 ?
3.1.1.8 indophenyl acetate + H2O
-
 Equus caballus ?
-
 ?
3.1.1.8 phenyl acetate + H2O
-
 Equus caballus phenol + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 ChE
-
 Equus caballus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.1.8 5 7.5 a decrease in pH from 7.5 to 5.0 is accompanied by a 20fold drop in the rate of enzymatic hydrolysis of acetylcholine and a 5fold decrease in the case of phenylacetate. In the case of indophenyl acetate and 2,6-dichlorophenolindophenyl acetate, only a 2.5fold decrease is detected Equus caballus