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Literature summary extracted from

  • Kamiya, H.; Hori, M.; Arimori, T.; Sekiguchi, M.; Yamagata, Y.; Harashima, H.
    NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity (2009), DNA Repair, 8, 1250-1254.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.58 0.0021
-
8-oxo-dGDP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.0029
-
8-oxo-dADP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.004
-
5-formyl-dUDP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.0076
-
dGDP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.0088
-
2-hydroxy-dADP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.0126
-
dADP pH 8.0, 30°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.58 Homo sapiens Q9UKK9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.58 2-hydroxy-dADP + H2O kcat/KM is 15% of the wild-type value Homo sapiens 2-hydroxy-dAMP + phosphate
-
?
3.6.1.58 5-formyl-dUDP + H2O kcat/KM is 30% of the wild-type value Homo sapiens 5-formyl-dUMP + phosphate
-
?
3.6.1.58 8-oxo-dADP + H2O 8-oxo-dADP is hydrolyzed slightly more efficiently than 8-oxo-dGDP Homo sapiens 8-oxo-dAMP + phosphate
-
?
3.6.1.58 8-oxo-dGDP + H2O NUDT5 protein is a hydrolyzing enzyme with broad substrate specificity for oxidized deoxyribonucleoside diphosphates Homo sapiens 8-oxo-dGMP + phosphate
-
?
3.6.1.58 dADP + H2O kcat/KM is 16% of the wild-type value Homo sapiens dAMP + phosphate
-
?
3.6.1.58 dGDP + H2O
-
Homo sapiens dGMP + phosphate
-
?
3.6.1.58 additional information the hydrolyses of 2-hydroxy-dADP and 5-formyl-dUDP are less effective, with 0.4- and 0.5-fold efficiencies relative to that of 8-oxo-dGDP, respectively. The hydrolyses of the triphosphate derivatives are less efficient than those of the diphosphate counterparts Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.58 NUDT5
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.6.1.58 30
-
assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6.1.58 0.0035
-
5-formyl-dUDP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.004
-
2-hydroxy-dADP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.006
-
dADP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.006
-
8-oxo-dGDP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.009
-
8-oxo-dADP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.015
-
dGDP pH 8.0, 30°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.58 8
-
assay at Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.6.1.58 0.45
-
2-hydroxy-dADP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.48
-
dADP pH 8.0, 30°C Homo sapiens
3.6.1.58 0.88
-
5-formyl-dUDP pH 8.0, 30°C Homo sapiens
3.6.1.58 2.9
-
8-oxo-dGDP pH 8.0, 30°C Homo sapiens
3.6.1.58 3.1
-
8-oxo-dADP pH 8.0, 30°C Homo sapiens