EC Number | Cloned (Comment) | Organism |
---|---|---|
3.1.3.53 | the lethal mutation FP41 is a missense mutation changing one of the six highly conserved residues in the catalytic domain, D222N in flw-PA and D91N in flw-PB, it is mapped by meiotic recombination with visible recessive markers to the region between cut (7B4) and vermilion (9F11) and between P-elements PBac(WH)CG34408f03664 (9B7) and PBac(WH)Neb-cGPf02352 (9C4), sequence determination of the wild-type and mutant gene from genomic DNA from single FP41/Y larvae and controls | Drosophila melanogaster |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.3.53 | Drosophila melanogaster | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.1.3.53 | oocyte | - |
Drosophila melanogaster | - |
3.1.3.53 | ovarian follicle | - |
Drosophila melanogaster | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.3.53 | PP1beta | - |
Drosophila melanogaster |
3.1.3.53 | protein phosphatase 1beta | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.1.3.53 | malfunction | a loss-of-function mutation of flapwing, which encodes the catalytic subunit of protein phosphatase 1beta, disrupts oocyte polarization. Proliferation and differentiation of the posterior follicle cells are affected by FP41, also FP41 mutation disrupts cell differentiation and Notch signaling of the cells. Excessive myosin activity in the posterior follicle cells causes oocyte mispolarization and defective Notch signaling and endocytosis in the posterior follicle cells, phenotype, detailed overview. The Notch intracellular domain can rescue the Notch signaling phenotype, but not the oocyte polarity phenotype of flwFP41 mutant cells | Drosophila melanogaster |
3.1.3.53 | physiological function | PP1beta, by regulating myosin activity, controls the generation of the oocyte polarizing signal, it is essential for dephosphorylation and inactivation of the non-muscle myosin II light chain encoded by spaghetti squash. PP1beta regulates the membrane levels of apical complexes in the posterior follicle cells | Drosophila melanogaster |