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Literature summary extracted from

  • Zhang, Y.; Zhang, Y.; Gao, Y.; Zhao, X.; Wang, Z.
    Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation (2011), Dev. Biol., 353, 259-265.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.3 dACS1, genotyping Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
6.2.1.3 K294E naturally occuring mutant of dAcs1, K294E is located in the AMP-binding domain Drosophila melanogaster
6.2.1.3 Q419R naturally occuring mutant of dAcs1 Drosophila melanogaster
6.2.1.3 W685stop naturally occuring mutant of dAcs1, W685stop removes the last 33 amino acids Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Drosophila melanogaster
-
 isozyme dAcsl
-

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL
-
 Drosophila melanogaster
6.2.1.3 dAcsl
-
 Drosophila melanogaster
6.2.1.3 long-chain acyl-CoA synthetase
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
6.2.1.3 malfunction abdominal segmentation defects of dAcsl mutants resemble those of gap gene knirps. The central expression domain of Kni transcripts or proteins is reduced whereas the adjacent domains of another gap gene Hunchback are correspondingly expanded in these mutants. Consequently, the striped pattern of the pair-rule gene Even-skipped is disrupted, phenotype, overview Drosophila melanogaster
6.2.1.3 physiological function dAcsl is the Drosophila homolog of human ACSL4 and their functions are highly conserved in the processes ranging from lipid metabolism to the establishment of visual wiring, both maternal and zygotic dAcsl are required for embryonic segmentation Drosophila melanogaster