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Literature summary extracted from
- The inositol 5-phosphatase dOCRL controls PI(4,5)P2 homeostasis and is necessary for cytokinesis (2011), Curr. Biol., 21, 1074-1079.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.1.3.36 | endosome | dOCRL is associated with endosomes | Drosophila melanogaster | 5768 | - |
| 3.1.3.36 | membrane | dOCRL dephosphorylates PI(4,5)P2 on internal membranes | Drosophila melanogaster | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.36 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | Drosophila melanogaster | - |
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.36 | Drosophila melanogaster | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.36 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O | - |
Drosophila melanogaster | 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.3.36 | dOCRL | orthologue of the human oculocerebrorenal syndrome of Lowe 1, i.e. OCRL1 | Drosophila melanogaster |
| 3.1.3.36 | inositol 5-phosphatase | - |
Drosophila melanogaster |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.3.36 | malfunction | in absence of dOCRL, several essential components of the cleavage furrow are found to be incorrectly localized on giant cytoplasmic vacuoles rich in PI(4,5)P2 and in endocytic markers | Drosophila melanogaster |
| 3.1.3.36 | physiological function | dOCRL is essential for cytokinesis and cell division, it dephosphorylates phosphatidylinositol-4,5-bisphosphate on internal membranes to restrict this phosphoinositide at the plasma membrane and thereby regulates cleavage furrow formation and ingression. dOCRL is required for proper furrowing of the contractile ring and proper assembly | Drosophila melanogaster |
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Release 2023.1 (January 2023)
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