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Literature summary extracted from
- Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment (2011), Clin. Cancer Res., 17, 2777-2787.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.6.2.1 | (S)-camptothecin | - |
Homo sapiens |  |
| 5.6.2.1 | (S)-camptothecin | - |
Mus musculus | |
| 5.6.2.1 | 8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one | i.e. ARC-111 | Homo sapiens | |
| 5.6.2.1 | 8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one | i.e. ARC-111 | Mus musculus | |
| 5.6.2.1 | 8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one | i.e. Genz-644282 | Homo sapiens | |
| 5.6.2.1 | 8,9-dimethoxy-5-(2-N-methylaminoethyl)-2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-one | i.e. Genz-644282 | Mus musculus | |
| 5.6.2.1 | additional information | topoisomerase I inhibitors act as anticancer drugs, overview. Bone marrow colony-forming unit, CFU, granulocyte macrophage CFU, and tumor cell CFU activity of topoisomerase I inhibitors, overview. CFU are bipotent hemopoietic stem cells. Human bone marrow colony-forming unit is more sensitive to the Top1 inhibitors than is mouse bone marrow colony-forming unit | Homo sapiens | |
| 5.6.2.1 | additional information | topoisomerase I inhibitors act as anticancer drugs, overview. Bone marrow colony-forming unit, CFU, granulocyte macrophage CFU, and tumor cell CFU activity of topoisomerase I inhibitors, overview. CFU are bipotent hemopoietic stem cells. Human bone marrow colony-forming unit is more sensitive to the Top1 inhibitors than is mouse bone marrow colony-forming unit | Mus musculus | |
| 5.6.2.1 | SN-38 | - |
Homo sapiens | |
| 5.6.2.1 | SN-38 | - |
Mus musculus | |
| 5.6.2.1 | topotecan | - |
Homo sapiens | |
| 5.6.2.1 | topotecan | - |
Mus musculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.6.2.1 | nucleus | - |
Mus musculus | 5634 | - |
| 5.6.2.1 | nucleus | - |
Homo sapiens | 5634 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.6.2.1 | Homo sapiens | - |
- |
- |
| 5.6.2.1 | Mus musculus | - |
male mice | - |
| 5.6.2.1 | Mus musculus BALB/c | - |
male mice | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.6.2.1 | bone marrow cell | - |
Mus musculus | - |
| 5.6.2.1 | bone marrow cell | - |
Homo sapiens | - |
| 5.6.2.1 | colonic cancer cell | - |
Homo sapiens | - |
| 5.6.2.1 | DLD-1 cell | - |
Homo sapiens | - |
| 5.6.2.1 | HCT-116 cell | - |
Homo sapiens | - |
| 5.6.2.1 | HCT-15 cell | - |
Homo sapiens | - |
| 5.6.2.1 | hematopoietic stem cell | bipotent hemopoietic stem cells | Mus musculus | - |
| 5.6.2.1 | hematopoietic stem cell | bipotent hemopoietic stem cells | Homo sapiens | - |
| 5.6.2.1 | HT-29 cell | - |
Homo sapiens | - |
| 5.6.2.1 | KB-3-1 cell | - |
Homo sapiens | - |
| 5.6.2.1 | KB-V1 cell | - |
Homo sapiens | - |
| 5.6.2.1 | KBH5.0 cell | - |
Homo sapiens | - |
| 5.6.2.1 | MDA-MB-231 cell | - |
Homo sapiens | - |
| 5.6.2.1 | melanoma cell | - |
Homo sapiens | - |
| 5.6.2.1 | non-small cell lung cancer cell | - |
Homo sapiens | - |
| 5.6.2.1 | RCC 786-O cell | - |
Homo sapiens | - |
| 5.6.2.1 | renal cell carcinoma cell | - |
Homo sapiens | - |
| 5.6.2.1 | RPMI-8226 cell | - |
Homo sapiens | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.6.2.1 | Top1 | - |
Mus musculus |
| 5.6.2.1 | Top1 | - |
Homo sapiens |
| 5.6.2.1 | Topoisomerase I | - |
Mus musculus |
| 5.6.2.1 | Topoisomerase I | - |
Homo sapiens |
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