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Literature summary extracted from
- 1-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed sigma and human DELTA8-DELTA7 sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity (2011), ChemMedChem, 6, 73-80.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.3.5 | (+)-pentazocine | i.e. (+)-[2S-(2R,6R,11R)]-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-2,6-methano-3-benzazocine-8-ol | Homo sapiens |  |
| 5.3.3.5 | (+/-)-ifenprodil | - |
Homo sapiens | |
| 5.3.3.5 | (R,S)-1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1,3-di-2-tolylguanidine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[cis-4-(2,6-difluorophenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[cis-4-(2,6-dimethoxyphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[cis-4-(2-methoxyphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[cis-4-(2-methylphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[cis-4-(4-methoxyphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[trans-4-(2,6-difluorophenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[trans-4-(2,6-dimethoxyphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[trans-4-(2-methoxyphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[trans-4-(2-methylphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-cyclohexyl-4-[trans-4-(4-methoxyphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-[cis-4-(2-chlorophenyl)cyclohexyl]-4-cyclohexylpiperazine | - |
Homo sapiens | |
| 5.3.3.5 | 1-[trans-4-(2-chlorophenyl)cyclohexyl]-4-cyclohexylpiperazine | - |
Homo sapiens | |
| 5.3.3.5 | cis-1-cyclohexyl-4-(4-phenylcyclohexyl)piperazine | - |
Homo sapiens | |
| 5.3.3.5 | cis-1-cyclohexyl-4-[(3-methoxyphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
| 5.3.3.5 | cis-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine | - |
Homo sapiens | |
| 5.3.3.5 | trans-1-cyclohexyl-4-(4-phenylcyclohexyl)piperazine | - |
Homo sapiens | |
| 5.3.3.5 | trans-1-cyclohexyl-4-[(3-methoxyphenyl)cyclohexyl]piperazine | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.3.5 | Homo sapiens | - |
- |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.3.5 | Delta8-delta7 sterol isomerase | - |
Homo sapiens |
| 5.3.3.5 | HSI | - |
Homo sapiens |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.3.5 | 0.0000004 | - |
trans-1-cyclohexyl-4-[(3-methoxyphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000041 | - |
1-cyclohexyl-4-[cis-4-(2-methoxyphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.00000495 | - |
cis-4-[4-(2,6-dimethoxyphenyl)cyclohexyl]-1-(2-pyridinyl)piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.00000651 | - |
1-cyclohexyl-4-[cis-4-(4-methoxyphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000076 | - |
1-cyclohexyl-4-[cis-4-(2,6-dimethoxyphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.000009 | - |
1-cyclohexyl-4-[cis-4-(2-methylphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.00000973 | - |
1-cyclohexyl-4-[trans-4-(2-methylphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000107 | - |
1-cyclohexyl-4-[trans-4-(2-methoxyphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.000011 | - |
1-cyclohexyl-4-[trans-4-(2,6-dimethoxyphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000123 | - |
cis-1-cyclohexyl-4-(4-phenylcyclohexyl)piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000126 | - |
cis-1-cyclohexyl-4-[(3-methoxyphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000136 | - |
1-cyclohexyl-4-[trans-4-(4-methoxyphenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000142 | - |
trans-1-cyclohexyl-4-(4-phenylcyclohexyl)piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000147 | - |
(+/-)-ifenprodil | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.000016 | - |
1-cyclohexyl-4-[cis-4-(2,6-difluorophenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000169 | - |
1-[cis-4-(2-chlorophenyl)cyclohexyl]-4-cyclohexylpiperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.000018 | - |
1-cyclohexyl-4-[trans-4-(2,6-difluorophenyl)cyclohexyl]piperazine | pH and temperature not specified in the publication | Homo sapiens | |
| 5.3.3.5 | 0.0000206 | - |
1-[trans-4-(2-chlorophenyl)cyclohexyl]-4-cyclohexylpiperazine | pH and temperature not specified in the publication | Homo sapiens | |
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