EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(phenylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(phenylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(phenylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Streptomyces coelicolor | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(pyridin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(pyridin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(pyridin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Streptomyces coelicolor | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(quinolin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(quinolin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(quinolin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Streptomyces coelicolor | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(thiophen-2-ylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(thiophen-2-ylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-(thiophen-2-ylethynyl)cyclohex-2-ene-1-carboxylic acid | - |
Streptomyces coelicolor | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-[(3-nitrophenyl)ethynyl]cyclohex-2-ene-1-carboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-[(3-nitrophenyl)ethynyl]cyclohex-2-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-[(3-nitrophenyl)ethynyl]cyclohex-2-ene-1-carboxylic acid | - |
Streptomyces coelicolor | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-[[3-(trifluoromethyl)phenyl]ethynyl]cyclohex-2-ene-1-carboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-[[3-(trifluoromethyl)phenyl]ethynyl]cyclohex-2-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,4R,5R)-1,4,5-trihydroxy-3-[[3-(trifluoromethyl)phenyl]ethynyl]cyclohex-2-ene-1-carboxylic acid | - |
Streptomyces coelicolor | |
4.2.1.10 | (1R,4R,5R)-3-(1,3-benzothiazol-2-ylethynyl)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,4R,5R)-3-(1,3-benzothiazol-2-ylethynyl)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,4R,5R)-3-(1,3-benzothiazol-2-ylethynyl)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | - |
Streptomyces coelicolor | |
4.2.1.10 | (1R,4R,5R)-3-[(4-fluorophenyl)ethynyl]-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | - |
Helicobacter pylori | |
4.2.1.10 | (1R,4R,5R)-3-[(4-fluorophenyl)ethynyl]-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | - |
Mycobacterium tuberculosis | |
4.2.1.10 | (1R,4R,5R)-3-[(4-fluorophenyl)ethynyl]-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | - |
Streptomyces coelicolor | |
4.2.1.10 | additional information | development of a range of ene-yne-based inhibitors, active site docking study using enzyme structure PDB ID 2WKS, overview | Helicobacter pylori | |
4.2.1.10 | additional information | development of a range of ene-yne-based inhibitors, overview | Mycobacterium tuberculosis | |
4.2.1.10 | additional information | development of a range of ene-yne-based inhibitors, active site docking study using enzyme structure PDB ID 1GU1, overview | Streptomyces coelicolor |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.10 | 0.036 | - |
3-dehydroquinate | pH 7.5, 25°C | Mycobacterium tuberculosis | |
4.2.1.10 | 0.075 | - |
3-dehydroquinate | pH 7.5, 25°C | Helicobacter pylori | |
4.2.1.10 | 0.21 | - |
3-dehydroquinate | pH 7.5, 25°C | Streptomyces coelicolor |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.10 | 3-dehydroquinate | Mycobacterium tuberculosis | - |
3-dehydroshikimate + H2O | - |
r | |
4.2.1.10 | 3-dehydroquinate | Streptomyces coelicolor | - |
3-dehydroshikimate + H2O | - |
r | |
4.2.1.10 | 3-dehydroquinate | Helicobacter pylori | - |
3-dehydroshikimate + H2O | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.2.1.10 | Helicobacter pylori | Q48255 | - |
- |
4.2.1.10 | Mycobacterium tuberculosis | - |
- |
- |
4.2.1.10 | Streptomyces coelicolor | P15474 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.2.1.10 | 3-dehydroquinate | - |
Mycobacterium tuberculosis | 3-dehydroshikimate + H2O | - |
r | |
4.2.1.10 | 3-dehydroquinate | - |
Streptomyces coelicolor | 3-dehydroshikimate + H2O | - |
r | |
4.2.1.10 | 3-dehydroquinate | - |
Helicobacter pylori | 3-dehydroshikimate + H2O | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.2.1.10 | dehydroquinase | - |
Mycobacterium tuberculosis |
4.2.1.10 | dehydroquinase | - |
Streptomyces coelicolor |
4.2.1.10 | dehydroquinase | - |
Helicobacter pylori |
4.2.1.10 | DHQase | - |
Mycobacterium tuberculosis |
4.2.1.10 | DHQase | - |
Streptomyces coelicolor |
4.2.1.10 | DHQase | - |
Helicobacter pylori |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
4.2.1.10 | 25 | - |
assay at | Mycobacterium tuberculosis |
4.2.1.10 | 25 | - |
assay at | Streptomyces coelicolor |
4.2.1.10 | 25 | - |
assay at | Helicobacter pylori |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.2.1.10 | 0.34 | - |
3-dehydroquinate | pH 7.5, 25°C | Helicobacter pylori | |
4.2.1.10 | 4.6 | - |
3-dehydroquinate | pH 7.5, 25°C | Mycobacterium tuberculosis | |
4.2.1.10 | 61 | - |
3-dehydroquinate | pH 7.5, 25°C | Streptomyces coelicolor |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
4.2.1.10 | 7.5 | - |
assay at | Mycobacterium tuberculosis |
4.2.1.10 | 7.5 | - |
assay at | Streptomyces coelicolor |
4.2.1.10 | 7.5 | - |
assay at | Helicobacter pylori |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
4.2.1.10 | 0.0000022 | - |
pH 7.5, 25°C | Streptomyces coelicolor | (1R,4R,5R)-1,4,5-trihydroxy-3-[(3-nitrophenyl)ethynyl]cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.0000069 | - |
pH 7.5, 25°C | Streptomyces coelicolor | (1R,4R,5R)-1,4,5-trihydroxy-3-[[3-(trifluoromethyl)phenyl]ethynyl]cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.0000071 | - |
pH 7.5, 25°C | Streptomyces coelicolor | (1R,4R,5R)-1,4,5-trihydroxy-3-(thiophen-2-ylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.0000075 | - |
pH 7.5, 25°C | Streptomyces coelicolor | (1R,4R,5R)-3-(1,3-benzothiazol-2-ylethynyl)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000012 | - |
pH 7.5, 25°C | Streptomyces coelicolor | (1R,4R,5R)-3-[(4-fluorophenyl)ethynyl]-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000028 | - |
pH 7.5, 25°C | Streptomyces coelicolor | (1R,4R,5R)-1,4,5-trihydroxy-3-(phenylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000094 | - |
pH 7.5, 25°C | Helicobacter pylori | (1R,4R,5R)-3-(1,3-benzothiazol-2-ylethynyl)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000098 | - |
pH 7.5, 25°C | Helicobacter pylori | (1R,4R,5R)-1,4,5-trihydroxy-3-[(3-nitrophenyl)ethynyl]cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000103 | - |
pH 7.5, 25°C | Helicobacter pylori | (1R,4R,5R)-1,4,5-trihydroxy-3-[[3-(trifluoromethyl)phenyl]ethynyl]cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000106 | - |
pH 7.5, 25°C | Helicobacter pylori | (1R,4R,5R)-3-[(4-fluorophenyl)ethynyl]-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000108 | - |
pH 7.5, 25°C | Mycobacterium tuberculosis | (1R,4R,5R)-1,4,5-trihydroxy-3-[[3-(trifluoromethyl)phenyl]ethynyl]cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000126 | - |
pH 7.5, 25°C | Mycobacterium tuberculosis | (1R,4R,5R)-3-(1,3-benzothiazol-2-ylethynyl)-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000133 | - |
pH 7.5, 25°C | Mycobacterium tuberculosis | (1R,4R,5R)-1,4,5-trihydroxy-3-[(3-nitrophenyl)ethynyl]cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000168 | - |
pH 7.5, 25°C | Streptomyces coelicolor | (1R,4R,5R)-1,4,5-trihydroxy-3-(quinolin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000171 | - |
pH 7.5, 25°C | Streptomyces coelicolor | (1R,4R,5R)-1,4,5-trihydroxy-3-(pyridin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000187 | - |
pH 7.5, 25°C | Mycobacterium tuberculosis | (1R,4R,5R)-1,4,5-trihydroxy-3-(thiophen-2-ylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000253 | - |
pH 7.5, 25°C | Helicobacter pylori | (1R,4R,5R)-1,4,5-trihydroxy-3-(phenylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000316 | - |
pH 7.5, 25°C | Helicobacter pylori | (1R,4R,5R)-1,4,5-trihydroxy-3-(thiophen-2-ylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000356 | - |
pH 7.5, 25°C | Mycobacterium tuberculosis | (1R,4R,5R)-1,4,5-trihydroxy-3-(phenylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000548 | - |
pH 7.5, 25°C | Mycobacterium tuberculosis | (1R,4R,5R)-3-[(4-fluorophenyl)ethynyl]-1,4,5-trihydroxycyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000712 | - |
pH 7.5, 25°C | Helicobacter pylori | (1R,4R,5R)-1,4,5-trihydroxy-3-(pyridin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.000885 | - |
pH 7.5, 25°C | Mycobacterium tuberculosis | (1R,4R,5R)-1,4,5-trihydroxy-3-(quinolin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.001203 | - |
pH 7.5, 25°C | Helicobacter pylori | (1R,4R,5R)-1,4,5-trihydroxy-3-(quinolin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid | |
4.2.1.10 | 0.002194 | - |
pH 7.5, 25°C | Mycobacterium tuberculosis | (1R,4R,5R)-1,4,5-trihydroxy-3-(pyridin-3-ylethynyl)cyclohex-2-ene-1-carboxylic acid |
EC Number | General Information | Comment | Organism |
---|---|---|---|
4.2.1.10 | metabolism | dehydroquinase catalyzes the third step in the shikimate pathway, the reversible dehydration of 3-dehydroquinate to 3-dehydroshikimate | Mycobacterium tuberculosis |
4.2.1.10 | metabolism | dehydroquinase catalyzes the third step in the shikimate pathway, the reversible dehydration of 3-dehydroquinate to 3-dehydroshikimate | Streptomyces coelicolor |
4.2.1.10 | metabolism | dehydroquinase catalyzes the third step in the shikimate pathway, the reversible dehydration of 3-dehydroquinate to 3-dehydroshikimate | Helicobacter pylori |