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Literature summary extracted from

  • Nomura, D.K.; Long, J.Z.; Niessen, S.; Hoover, H.S.; Ng, S.W.; Cravatt, B.F.
    Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis (2010), Cell, 140, 49-61.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.23 JZL184 irreversible inhibitor Homo sapiens
3.1.1.23 N-arachidonoyl dopamine
-
 Homo sapiens
3.1.1.23 troglitazone
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.23 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.23 MCF-7 cell
-
 Homo sapiens
-
3.1.1.23 MDA-MB-231 cell
-
 Homo sapiens
-
3.1.1.23 MUM-2B cell
-
 Homo sapiens
-
3.1.1.23 MUM-2C cell
-
 Homo sapiens
-
3.1.1.23 OVCAR-3 cell
-
 Homo sapiens
-
3.1.1.23 SKOV-3 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.23 MAGL
-
 Homo sapiens
3.1.1.23 monoacylglycerol lipase
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.1.1.23 Homo sapiens monoacylglycerol lipase is highly expressed in aggressive human cancer cells and primary tumors up

General Information

EC Number General Information Comment Organism
3.1.1.23 malfunction disruption of MAGL expression and activity impairs cancer pathogenicity. impairments in MAGL-dependent tumor growth are rescued by a high-fat diet, indicating that exogenous sources of fatty acids can contribute to malignancy in cancers lacking MAGL activity Homo sapiens
3.1.1.23 physiological function monoacylglycerol lipase (MAGL) regulates a fatty acid network that promotes cancer pathogenesis. MAGL, through hydrolysis of monoacylglycerols, controls free fatty acid levels in cancer cells Homo sapiens