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Literature summary extracted from

  • Mullaney, B.C.; Blind, R.D.; Lemieux, G.A.; Perez, C.L.; Elle, I.C.; Faergeman, N.J.; Van Gilst, M.R.; Ingraham, H.A.; Ashrafi, K.
    Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25 (2010), Cell Metab., 12, 398-410.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.2.1.3 gene acs-3, expression as GFP-tagged protein in worm embryos Caenorhabditis elegans

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Caenorhabditis elegans
-
 isozyme ACS-3, gene acs-3
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 adult tissue expression patterns of acs-3, overview Caenorhabditis elegans
-
6.2.1.3 epidermal cell
-
 Caenorhabditis elegans
-
6.2.1.3 larva tissue expression patterns of acs-3, overview Caenorhabditis elegans
-
6.2.1.3 seam cell
-
 Caenorhabditis elegans
-

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACS-3
-
 Caenorhabditis elegans
6.2.1.3 acyl-CoA synthase-3
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
6.2.1.3 malfunction loss of ACS-3, a long-chain acyl-CoA synthase, causes enhanced intestinal lipid uptake, de novo fat synthesis, and accumulation of enlarged, neutral lipid-rich intestinal depots. Acs-3 mutant phenotypes require the nuclear hormone receptor NHR-25, a key regulator of Caenorhabditis elegans molting Caenorhabditis elegans
6.2.1.3 additional information mutation of nhr-25 suppresses the fatty acid uptake phenotypes of acs-3(ft5) animals, overview Caenorhabditis elegans
6.2.1.3 physiological function regulation of Caenorhabditis elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25, overview. ACS-3-derived long-chain fatty acyl-CoAs, perhaps incorporated into complex ligands such as phosphoinositides, modulate NHR-25 function, which in turn regulates an endocrine program of lipid uptake and synthesis Caenorhabditis elegans