EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.1 | cAMP | the stimulatory effect of cAMP on adenylyl cyclase activity is enhanced in the presence of 0.005 mM Ca2+ and decreased in the presence of 0.1 mM Ca2+ | Tetrahymena pyriformis | |
4.6.1.1 | D-glucose | the stimulatory effect of D-glucose does not change in the presence of Ca2+ and calmodulin antagonists chloropromazine, N-(6-aminohexyl)-1-naphthalenesulfonamide hydrochloride, and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride | Tetrahymena pyriformis | |
4.6.1.1 | EGF | the stimulatory effect of EGF on adenylyl cyclase activity is enhanced in the presence of 0.005 mM Ca2+ and decreased in the presence of 0.1 mM Ca2+ | Tetrahymena pyriformis | |
4.6.1.1 | Insulin | the stimulatory effect of insulin on adenylyl cyclase is decreased to 28% in the presence of 0.1 mM Ca2+ | Tetrahymena pyriformis | |
4.6.1.1 | serotonin | the stimulatory effect of serotonin on adenylyl cyclase activity (253%) is enhanced in the presence of 0.005 mM Ca2+ | Tetrahymena pyriformis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.1 | Ca2+ | at 0.1 mM and higher, the calcium cations inhibit the adenylyl cyclase activity | Tetrahymena pyriformis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.1 | Ca2+ | maximum stimulatory effect at 0.002 mM Ca2+. (increase of 387% activity). Antagonists of calmodulin, N-(6-aminohexyl)-1-naphthalenesulfonamide hydrochloride and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride, at concentrations of 0.02-0.1 mM decrease the stimulatory effect of 0.005 mM Ca2+, while at the higher concentrations inhibit it completely. Chloropromazine decreases the Ca2+-stimulated adenylyl cyclase activity only at concentrations of 0.2-1.0 mM | Tetrahymena pyriformis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.1 | Tetrahymena pyriformis | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.1 | ATP | - |
Tetrahymena pyriformis | 3',5'-cyclic-AMP + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.6.1.1 | adenylyl cyclase | - |
Tetrahymena pyriformis |
4.6.1.1 | ATP-pyrophosphate lyase cyclizing | - |
Tetrahymena pyriformis |