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Literature summary extracted from

  • Vage, D.I.; Boman, I.A.
    A nonsense mutation in the beta-carotene oxygenase 2 (BCO2) gene is tightly associated with accumulation of carotenoids in adipose tissue in sheep (Ovis aries) (2010), BMC Genet., 11, 10.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.13.11.63 diagnostics genotyping AI rams for c.196C-T can be used in selection against the yellow fat trait Ovis aries
1.13.11.71 agriculture a nonsense mutation c.196C>T in the beta-carotene oxygenase 2 gene is found to strongly associate with the yellow fat phenotype in sheep. The existence of individuals lacking this mutation, but still demonstrating yellow fat, suggests that additional mutations may cause a similar phenotype in this population. Animals homozygous for the mutation are not reported to suffer from any negative health or development traits, pointing towards a minor role of BCO2 in vitamin A formation Ovis aries

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.63 gene bcmo1, DNA and amino acid sequence determination and analysis Ovis aries
1.13.11.63 gene bco2, DNA and amino acid sequence determination and analysis of wild-type and mutant enzymes, genotyping, overview Ovis aries

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.63 Ovis aries C1L3B1 gene bco2; gene BCO2
-
1.13.11.63 Ovis aries C7C6F6 gene bmco1; gene Bcmo1
-
1.13.11.71 Ovis aries C1L3B1
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.63 adipose tissue
-
 Ovis aries
-

Synonyms

EC Number Synonyms Comment Organism
1.13.11.63 Bcmo1
-
 Ovis aries
1.13.11.63 BCO2
-
 Ovis aries
1.13.11.63 beta-carotene 15,15'-monooxygenase 1
-
 Ovis aries
1.13.11.63 beta-carotene oxygenase 2
-
 Ovis aries

General Information

EC Number General Information Comment Organism
1.13.11.71 physiological function a nonsense mutation c.196C>T in the beta-carotene oxygenase 2 gene is found to strongly associate with the yellow fat phenotype in sheep. The existence of individuals lacking this mutation, but still demonstrating yellow fat, suggests that additional mutations may cause a similar phenotype in this population. Animals homozygous for the mutation are not reported to suffer from any negative health or development traits, pointing towards a minor role of BCO2 in vitamin A formation Ovis aries
1.14.99.36 malfunction a nonsense mutation c.196C-T in the beta-carotene oxygenase 2 BCO2 gene is strongly associated with the yellow fat phenotype in sheep that is caused by accumulation of carotenoids in adipose tissue, a recessive trait. But animals homozygous for the mutation do not suffer from any negative health or development traits, pointing towards a minor role of BCO2 in vitamin A formation Ovis aries
1.14.99.36 physiological function quantitatively important role for BCO2 in carotenoid degradation, which might indicate a broad enzyme specificity for carotenoids Ovis aries