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Literature summary extracted from

  • Huang, L.; Luo, Z.; He, F.; Lu, J.; Li, X.
    Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase (2010), Bioorg. Med. Chem., 18, 4475-4484.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 1,2-di(berberine-9-O-yl)ethane dibromide
-
 Equus caballus
3.1.1.8 1,3-di(berberine-9-O-yl)propane dibromide
-
 Equus caballus
3.1.1.8 10-methoxy-9-(4-phenoxybutoxy)-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium bromide
-
 Equus caballus
3.1.1.8 9-O-[(2-(3-methyl)pyridinium bromide)ethyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[(2-pyridinium)bromide ethyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[(3-o xo-3-p-chlorophenylamino)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[(3-oxo-3-p-methoxyamino)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[(3-oxo-3-p-nitrophenylamino)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[(3-oxo-3-p-tolylamino)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[(3-oxo-3-phenylamino)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[(3-pyridinium bromide)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(2-pyridinoxyl)butyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(3-methyl pyridinium bromide)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(4-bromo-phenoxyl)butyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(4-bromo-phenoxyl)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(4-chloro-phenoxyl) butyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(4-chloro-phenoxyl)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(4-methoxy-phenoxyl)-propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(4-methoxy-phenoxyl)butyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(4-methyl-phenoxyl) propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(4-nitro-phenoxyl)butyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(4-nitro-phenoxyl)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(N-methyl-phenylamino)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(naphthalen-2-yloxy)butyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(naphthalen-2-yloxy)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(naphthalene-2-ylthio)butyl]-berberine bromide most potent BuChE inhibito Equus caballus
3.1.1.8 9-O-[3-(naphthalene-2-ylthio)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 9-O-[3-(phenylamino)propyl]-berberine bromide
-
 Equus caballus
3.1.1.8 Berberine
-
 Equus caballus
3.1.1.8 galanthamine
-
 Equus caballus
3.1.1.8 tacrine
-
 Equus caballus

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Equus caballus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 serum
-
 Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.8 acetylthiocholine + H2O
-
 Equus caballus thiocholine + acetate
-
 ?
3.1.1.8 benzoylcholine + H2O
-
 Equus caballus choline + benzoate
-
 ?
3.1.1.8 butyrylthiocholine + H2O
-
 Equus caballus thiocholine + butyrate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BuChE
-
 Equus caballus
3.1.1.8 butyrylcholinesterase
-
 Equus caballus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.8 0.000078
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(naphthalene-2-ylthio)butyl]-berberine bromide
3.1.1.8 0.000231
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 1,3-di(berberine-9-O-yl)propane dibromide
3.1.1.8 0.000531
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 1,2-di(berberine-9-O-yl)ethane dibromide
3.1.1.8 0.000548
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(naphthalene-2-ylthio)propyl]-berberine bromide
3.1.1.8 0.00101
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[(3-oxo-3-p-methoxyamino)propyl]-berberine bromide
3.1.1.8 0.0011
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(naphthalen-2-yloxy)butyl]-berberine bromide
3.1.1.8 0.00111
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(3-methyl pyridinium bromide)propyl]-berberine bromide
3.1.1.8 0.00131
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[(3-oxo-3-p-tolylamino)propyl]-berberine bromide
3.1.1.8 0.00168
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[(3-o xo-3-p-chlorophenylamino)propyl]-berberine bromide
3.1.1.8 0.00176
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(phenylamino)propyl]-berberine bromide
3.1.1.8 0.0018
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(4-chloro-phenoxyl)propyl]-berberine bromide
3.1.1.8 0.00181
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(4-methyl-phenoxyl) propyl]-berberine bromide
3.1.1.8 0.00205
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(4-nitro-phenoxyl)butyl]-berberine bromide
3.1.1.8 0.00217
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(N-methyl-phenylamino)propyl]-berberine bromide
3.1.1.8 0.00218
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[(3-oxo-3-phenylamino)propyl]-berberine bromide
3.1.1.8 0.0022
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(4-chloro-phenoxyl) butyl]-berberine bromide
3.1.1.8 0.0022
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(naphthalen-2-yloxy)propyl]-berberine bromide
3.1.1.8 0.00229
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(4-methoxy-phenoxyl)butyl]-berberine bromide
3.1.1.8 0.00282
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[(2-pyridinium)bromide ethyl]-berberine bromide
3.1.1.8 0.00283
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(4-nitro-phenoxyl)propyl]-berberine bromide
3.1.1.8 0.00286
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(4-methoxy-phenoxyl)-propyl]-berberine bromide
3.1.1.8 0.00416
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(2-pyridinoxyl)butyl]-berberine bromide
3.1.1.8 0.00424
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(4-bromo-phenoxyl)propyl]-berberine bromide
3.1.1.8 0.00489
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 10-methoxy-9-(4-phenoxybutoxy)-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium bromide
3.1.1.8 0.00544
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[3-(4-bromo-phenoxyl)butyl]-berberine bromide
3.1.1.8 0.00553
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[(3-oxo-3-p-nitrophenylamino)propyl]-berberine bromide
3.1.1.8 0.0133
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[(3-pyridinium bromide)propyl]-berberine bromide
3.1.1.8 0.0157
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus galanthamine
3.1.1.8 0.0158
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus 9-O-[(2-(3-methyl)pyridinium bromide)ethyl]-berberine bromide
3.1.1.8 0.0182
-
 in 0.1 M KH2PO4/K2HPO4 buffer (pH 8.0), at 37°C Equus caballus tacrine