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Literature summary extracted from

  • Meza-Avina, M.E.; Wei, L.; Liu, Y.; Poduch, E.; Bello, A.M.; Mishra, R.K.; Pai, E.F.; Kotra, L.P.
    Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase (2010), Bioorg. Med. Chem., 18, 4032-4041.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.23
-
 Staphylococcus aureus
4.1.1.23
-
 Homo sapiens
4.1.1.23
-
 Saccharomyces cerevisiae
4.1.1.23
-
 Methanothermobacter thermautotrophicus
4.1.1.23
-
 Helicobacter pylori
4.1.1.23
-
 Plasmodium falciparum

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.1.1.23 hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with 4 and 10) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Saccharomyces cerevisiae
4.1.1.23 hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Staphylococcus aureus
4.1.1.23 hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Homo sapiens
4.1.1.23 hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Methanothermobacter thermautotrophicus
4.1.1.23 hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Helicobacter pylori
4.1.1.23 hanging drop vapor diffusion method, using 100 mM Tris-HCl, pH 8.4, 2.12 M ammonium sulfate (enzyme in complex with barbiturate ribonucleoside-5'-monophosphate and 1-(5-monophosphoryl-beta-D-ribofuranos-1-yl)-5-cyanouracil) or using 100 mM Tris-HCl, pH 8.4, 1.4 M ammonium sulfate (enzyme in complex with pyrazofurin-5'-monophosphate) Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.23 5-cyano-UMP poor inhibition Helicobacter pylori
4.1.1.23 5-cyano-UMP poor inhibition Homo sapiens
4.1.1.23 5-cyano-UMP poor inhibition Methanothermobacter thermautotrophicus
4.1.1.23 5-cyano-UMP poor inhibition Plasmodium falciparum
4.1.1.23 5-cyano-UMP poor inhibition Saccharomyces cerevisiae
4.1.1.23 5-cyano-UMP poor inhibition Staphylococcus aureus
4.1.1.23 barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Helicobacter pylori
4.1.1.23 barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Homo sapiens
4.1.1.23 barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Plasmodium falciparum
4.1.1.23 barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Saccharomyces cerevisiae
4.1.1.23 barbiturate ribonucleoside 5'-monophosphate very potent inhibitor Staphylococcus aureus
4.1.1.23 nifedipine competitive inhibition Helicobacter pylori
4.1.1.23 nifedipine competitive inhibition Homo sapiens
4.1.1.23 nifedipine competitive inhibition Methanothermobacter thermautotrophicus
4.1.1.23 nifedipine competitive inhibition Plasmodium falciparum
4.1.1.23 nifedipine competitive inhibition Saccharomyces cerevisiae
4.1.1.23 nifedipine competitive inhibition Staphylococcus aureus
4.1.1.23 nimodipine competitive inhibition Helicobacter pylori
4.1.1.23 nimodipine competitive inhibition Homo sapiens
4.1.1.23 nimodipine competitive inhibition Methanothermobacter thermautotrophicus
4.1.1.23 nimodipine competitive inhibition Plasmodium falciparum
4.1.1.23 nimodipine competitive inhibition Saccharomyces cerevisiae
4.1.1.23 nimodipine competitive inhibition Staphylococcus aureus
4.1.1.23 pyrazofurin also known as pyrazomycin, potent inhibitor Helicobacter pylori
4.1.1.23 pyrazofurin also known as pyrazomycin, potent inhibitor Homo sapiens
4.1.1.23 pyrazofurin also known as pyrazomycin, potent inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 pyrazofurin also known as pyrazomycin, potent inhibitor Plasmodium falciparum
4.1.1.23 pyrazofurin also known as pyrazomycin, potent inhibitor Saccharomyces cerevisiae
4.1.1.23 pyrazofurin also known as pyrazomycin, potent inhibitor Staphylococcus aureus
4.1.1.23 pyrazofurin-5'-monophosphate slow tight binding inhibitor Helicobacter pylori
4.1.1.23 pyrazofurin-5'-monophosphate slow tight binding inhibitor Homo sapiens
4.1.1.23 pyrazofurin-5'-monophosphate slow tight binding inhibitor Methanothermobacter thermautotrophicus
4.1.1.23 pyrazofurin-5'-monophosphate slow tight binding inhibitor Plasmodium falciparum
4.1.1.23 pyrazofurin-5'-monophosphate slow tight binding inhibitor Saccharomyces cerevisiae
4.1.1.23 pyrazofurin-5'-monophosphate slow tight binding inhibitor Staphylococcus aureus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.23 0.0017
-
 orotidine 5'-phosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Homo sapiens
4.1.1.23 0.0037
-
 orotidine 5'-phosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Methanothermobacter thermautotrophicus

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.23 Helicobacter pylori
-
-
-
4.1.1.23 Homo sapiens
-
-
-
4.1.1.23 Methanothermobacter thermautotrophicus
-
-
-
4.1.1.23 Plasmodium falciparum
-
-
-
4.1.1.23 Saccharomyces cerevisiae
-
-
-
4.1.1.23 Staphylococcus aureus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.1.23
-
 Staphylococcus aureus
4.1.1.23
-
 Homo sapiens
4.1.1.23
-
 Saccharomyces cerevisiae
4.1.1.23
-
 Methanothermobacter thermautotrophicus
4.1.1.23
-
 Helicobacter pylori
4.1.1.23
-
 Plasmodium falciparum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.23 Orotidine 5'-phosphate
-
 Staphylococcus aureus UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Homo sapiens UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Saccharomyces cerevisiae UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Methanothermobacter thermautotrophicus UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Helicobacter pylori UMP + CO2
-
 ?
4.1.1.23 Orotidine 5'-phosphate
-
 Plasmodium falciparum UMP + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.23 ODCase
-
 Staphylococcus aureus
4.1.1.23 ODCase
-
 Homo sapiens
4.1.1.23 ODCase
-
 Saccharomyces cerevisiae
4.1.1.23 ODCase
-
 Methanothermobacter thermautotrophicus
4.1.1.23 ODCase
-
 Helicobacter pylori
4.1.1.23 ODCase
-
 Plasmodium falciparum
4.1.1.23 Orotidine-5'-monophosphate decarboxylase
-
 Staphylococcus aureus
4.1.1.23 Orotidine-5'-monophosphate decarboxylase
-
 Homo sapiens
4.1.1.23 Orotidine-5'-monophosphate decarboxylase
-
 Saccharomyces cerevisiae
4.1.1.23 Orotidine-5'-monophosphate decarboxylase
-
 Methanothermobacter thermautotrophicus
4.1.1.23 Orotidine-5'-monophosphate decarboxylase
-
 Helicobacter pylori
4.1.1.23 Orotidine-5'-monophosphate decarboxylase
-
 Plasmodium falciparum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.23 0.000000009
-
 barbiturate ribonucleoside 5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Saccharomyces cerevisiae
4.1.1.23 0.000005
-
 pyrazofurin-5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Saccharomyces cerevisiae
4.1.1.23 0.000017
-
 pyrazofurin-5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Homo sapiens
4.1.1.23 0.00013
-
 pyrazofurin-5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Helicobacter pylori
4.1.1.23 0.0062
-
 pyrazofurin-5'-monophosphate in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Methanothermobacter thermautotrophicus
4.1.1.23 9.1
-
 5-cyano-UMP in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Plasmodium falciparum
4.1.1.23 290
-
 5-cyano-UMP in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Helicobacter pylori
4.1.1.23 550
-
 5-cyano-UMP in 50 mM Tris (pH 7.5), 20 mM dithiothreitol, and 40 mM NaCl, at 22°C Staphylococcus aureus