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Literature summary extracted from

  • Sriram, D.; Yogeeswari, P.; Methuku, S.; Vyas, D.R.; Senthilkumar, P.; Alvala, M.; Jeankumar, V.U.
    Synthesis of various 3-nitropropionamides as Mycobacterium tuberculosis isocitrate lyase inhibitor (2011), Bioorg. Med. Chem. Lett., 21, 5149-5154.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.1 1-(4-ethylpiperazin-1-yl)-3-nitropropan-1-one
-
 Mycobacterium tuberculosis
4.1.3.1 1-cyclopropyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
 Mycobacterium tuberculosis
4.1.3.1 1-cyclopropyl-7-(3,5-dimethyl-4-(3-nitropropanoyl)piperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
 Mycobacterium tuberculosis
4.1.3.1 1-ethyl-6,8-difluoro-7-[3-methyl-4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
 Mycobacterium tuberculosis
4.1.3.1 1-ethyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
 Mycobacterium tuberculosis
4.1.3.1 3-nitro-1-(4-phenylpiperazin-1-yl)propan-1-one
-
 Mycobacterium tuberculosis
4.1.3.1 3-nitro-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one
-
 Mycobacterium tuberculosis
4.1.3.1 3-nitropropionic acid
-
 Mycobacterium tuberculosis
4.1.3.1 N-(4-bromo-3-methylphenyl)-3-nitropropanamide
-
 Mycobacterium tuberculosis
4.1.3.1 N-(4-bromophenyl)-3-nitropropanamide
-
 Mycobacterium tuberculosis
4.1.3.1 N-(4-chlorophenyl)-3-nitropropanamide
-
 Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.1 Mycobacterium tuberculosis
-
-
-

Synonyms

EC Number Synonyms Comment Organism
4.1.3.1 isocitrate lyase
-
 Mycobacterium tuberculosis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4.1.3.1 0.0001
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 1-cyclopropyl-7-(3,5-dimethyl-4-(3-nitropropanoyl)piperazin-1-yl)-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
4.1.3.1 0.00012
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 1-cyclopropyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
4.1.3.1 0.0002
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 1-ethyl-6-fluoro-7-[4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
4.1.3.1 0.00146
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 1-ethyl-6,8-difluoro-7-[3-methyl-4-(3-nitropropanoyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
4.1.3.1 0.0126
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 1-(4-ethylpiperazin-1-yl)-3-nitropropan-1-one
4.1.3.1 0.02132
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis N-(4-chlorophenyl)-3-nitropropanamide
4.1.3.1 0.03018
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 3-nitro-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one
4.1.3.1 0.03246
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis N-(4-bromophenyl)-3-nitropropanamide
4.1.3.1 0.0368
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis N-(4-bromo-3-methylphenyl)-3-nitropropanamide
4.1.3.1 0.04121
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 3-nitro-1-(4-phenylpiperazin-1-yl)propan-1-one
4.1.3.1 0.116
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis 3-nitropropionic acid