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Literature summary extracted from

  • Kellenberger, E.; Kuhn, I.; Schuber, F.; Muller-Steffner, H.
    Flavonoids as inhibitors of human CD38 (2011), Bioorg. Med. Chem. Lett., 21, 3939-3942.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.6 the soluble ecto-domain of human CD38 is expressed in Pichia pastoris Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.2.6 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromenium
-
 Homo sapiens
3.2.2.6 cyanidin
-
 Homo sapiens
3.2.2.6 delphinidin
-
 Homo sapiens
3.2.2.6 fisetinidin
-
 Homo sapiens
3.2.2.6 kuromanin
-
 Homo sapiens
3.2.2.6 luteolin
-
 Homo sapiens
3.2.2.6 luteolinidin
-
 Homo sapiens
3.2.2.6 malvidin
-
 Homo sapiens
3.2.2.6 additional information not inhibited by rac-taxifolin, rac-catechin, piceatannol, and trans-resveratrol Homo sapiens
3.2.2.6 myricetin
-
 Homo sapiens
3.2.2.6 pelargonidin
-
 Homo sapiens
3.2.2.6 peonidin
-
 Homo sapiens
3.2.2.6 petunidin
-
 Homo sapiens
3.2.2.6 quercetagetin
-
 Homo sapiens
3.2.2.6 quercetagetinidin
-
 Homo sapiens
3.2.2.6 quercetin
-
 Homo sapiens
3.2.2.6 robinetin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.6 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.2.2.6
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.6 1,N6-etheno NAD+ + H2O
-
 Homo sapiens epsilon-ADP-ribose + nicotinamide + H+
-
 ?
3.2.2.6 additional information CD38 is a multifunctional enzyme catalyzing the conversion of NAD(P)+ to three metabolites (cyclic ADP-ribose, nicotinic acid adenine dinucleotide phosphate and ADP-ribose) Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.6 CD38
-
 Homo sapiens
3.2.2.6 NAD(P) nucleosidase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.2.6 0.006
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens luteolinidin
3.2.2.6 0.0063
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens kuromanin
3.2.2.6 0.0082
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens luteolin
3.2.2.6 0.0142
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens quercetagetinidin
3.2.2.6 0.0146
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens delphinidin
3.2.2.6 0.0163
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens pelargonidin
3.2.2.6 0.017
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens malvidin
3.2.2.6 0.0209
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens peonidin
3.2.2.6 0.0218
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens cyanidin
3.2.2.6 0.0248
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens myricetin
3.2.2.6 0.0321
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromenium
3.2.2.6 0.0379
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens quercetin
3.2.2.6 0.0379
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens robinetin
3.2.2.6 0.0392
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens petunidin
3.2.2.6 0.0486
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens quercetagetin
3.2.2.6 0.0703
-
 at 37°C in 10 mM potassium phosphate buffer, pH 7.4, containing 0.05% (w/v) emulphogene Homo sapiens fisetinidin