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Literature summary extracted from

  • Gutierrez-Lugo, M.T.; Bewley, C.A.
    Susceptibility and mode of binding of the Mycobacterium tuberculosis cysteinyl transferase mycothiol ligase to tRNA synthetase inhibitors (2011), Bioorg. Med. Chem. Lett., 21, 2480-2483.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.1.13 cysteinyl sulfamoyl adenosine selective, discrimination of aminoacyl-t-RNA synthetase inhibitors occurs at the amino acid moiety Mycobacterium tuberculosis
6.3.1.13 additional information not inhibitory: aminoacyl-t-RNA synthetase inhibitors ochratoxin A, borrelidin, cispentacin, mupirocin, seryl ulfamoyl adenosine, aspartyl ulfamoyl adenosine Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
6.3.1.13 Mycobacterium tuberculosis
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IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.3.1.13 0.00005
-
 pH not specified in the publication, temperature not specified in the publication Mycobacterium tuberculosis cysteinyl sulfamoyl adenosine