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Literature summary extracted from

  • Korabecny, J.; Musilek, K.; Holas, O.; Binder, J.; Zemek, F.; Marek, J.; Pohanka, M.; Opletalova, V.; Dohnal, V.; Kuca, K.
    Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease (2010), Bioorg. Med. Chem. Lett., 20, 6093-6095.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.8 7-methoxy-N-nonyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride (1:1)
-
 Homo sapiens
3.1.1.8 7-methoxy-N-octyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
 Homo sapiens
3.1.1.8 7-methoxy-N-pentyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
 Homo sapiens
3.1.1.8 7-methoxy-N-propyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
 Homo sapiens
3.1.1.8 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine
-
 Homo sapiens
3.1.1.8 N-butyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
 Homo sapiens
3.1.1.8 N-ethyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
 Homo sapiens
3.1.1.8 N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine
-
 Homo sapiens
3.1.1.8 N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
-
 Homo sapiens
3.1.1.8 tacrine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.8 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.8 blood plasma
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.8 BChE
-
 Homo sapiens
3.1.1.8 butyrylcholinesterase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.8 0.000023
-
 pH and temperature not specified in the publication Homo sapiens tacrine
3.1.1.8 0.00004
-
 pH and temperature not specified in the publication Homo sapiens N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
3.1.1.8 0.00012
-
 pH and temperature not specified in the publication Homo sapiens 7-methoxy-N-octyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
3.1.1.8 0.00036
-
 pH and temperature not specified in the publication Homo sapiens 7-methoxy-N-nonyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride (1:1)
3.1.1.8 0.001
-
 pH and temperature not specified in the publication Homo sapiens N-hexyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine
3.1.1.8 0.016
-
 pH and temperature not specified in the publication Homo sapiens 7-methoxy-N-pentyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
3.1.1.8 0.021
-
 pH and temperature not specified in the publication Homo sapiens 9-amino-7-methoxy-1,2,3,4-tetrahydroacridine
3.1.1.8 0.064
-
 pH and temperature not specified in the publication Homo sapiens N-butyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
3.1.1.8 0.07
-
 pH and temperature not specified in the publication Homo sapiens 7-methoxy-N-propyl-1,2,3,4-tetrahydroacridin-9-amine hydrochloride
3.1.1.8 0.097
-
 pH and temperature not specified in the publication Homo sapiens N-ethyl-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine hydrochloride