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Literature summary extracted from

  • Chonan, T.; Tanaka, H.; Yamamoto, D.; Yashiro, M.; Oi, T.; Wakasugi, D.; Ohoka-Sugita, A.; Io, F.; Koretsune, H.; Hiratate, A.
    Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors (2010), Bioorg. Med. Chem. Lett., 20, 3965-3968.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.4.1.2 (4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
-
Homo sapiens
6.4.1.2 1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
Homo sapiens
6.4.1.2 1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
Homo sapiens
6.4.1.2 1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
Homo sapiens
6.4.1.2 1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
Homo sapiens
6.4.1.2 1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
Homo sapiens
6.4.1.2 1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
Homo sapiens
6.4.1.2 1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
-
Homo sapiens
6.4.1.2 1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
-
Homo sapiens
6.4.1.2 4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
-
Homo sapiens
6.4.1.2 5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
-
Homo sapiens
6.4.1.2 5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.4.1.2 microsome
-
Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
6.4.1.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.4.1.2 liver
-
Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
6.4.1.2 ACC1 isoform Homo sapiens
6.4.1.2 ACC2 isoform Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.4.1.2 ATP
-
Homo sapiens
6.4.1.2 biotin
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.4.1.2 0.0000084
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-[4-[(4-[4-[(2-[2-[(dimethylamino)methyl]-3-methyl-2,3-dihydro-1H-indol-5-yl]-6-phenylpyridin-4-yl)carbonyl]piperazin-1-yl]piperidin-1-yl)carbonyl]piperidin-1-yl]ethanone
6.4.1.2 0.0000097
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-2-methyl-2,3-dihydro-1H-indole-3-carbonitrile
6.4.1.2 0.000021
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000027
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-[4-([4-[4-([2-[4-(2-hydroxyethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
6.4.1.2 0.00003
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(4-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.00003
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(3,4-dimethoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000032
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methoxyphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000033
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(2,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000033
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(3-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000036
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(3-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000037
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-(3-methylphenyl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000042
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-[4-([4-[4-([2-[4-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
6.4.1.2 0.000042
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1H-indazol-6-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000047
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(4-hydroxyphenyl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000047
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-[4-([4-[4-([2-[3-(hydroxymethyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
6.4.1.2 0.000047
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-[4-([4-[4-([2-[4-(2-hydroxyethoxy)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
6.4.1.2 0.000047
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1H-indol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000048
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(4-fluorophenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000049
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(3-fluoro-4-methylphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000054
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 5-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]-1,3-dihydro-2H-indol-2-one
6.4.1.2 0.000055
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000057
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1H-indazol-7-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000059
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000061
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(3-fluoro-4-methoxyphenyl)-6-(1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000069
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.00007
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-[4-([4-[4-([2-[4-(3-hydroxypropyl)phenyl]-6-phenylpyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
6.4.1.2 0.000072
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
6.4.1.2 0.000075
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens (4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]phenyl)acetic acid
6.4.1.2 0.00008
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 4-[4-[(4-[1-[(1-acetylpiperidin-4-yl)carbonyl]piperidin-4-yl]piperazin-1-yl)carbonyl]-6-phenylpyridin-2-yl]benzamide
6.4.1.2 0.0001
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-[4-([4-[4-([2-(1H-indol-5-yl)-6-[3-(trifluoromethyl)phenyl]pyridin-4-yl]carbonyl)piperazin-1-yl]piperidin-1-yl]carbonyl)piperidin-1-yl]ethanone
6.4.1.2 0.000105
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-phenyl-6-(1,2,3-trimethyl-2,3-dihydro-1H-indol-5-yl)pyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000117
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1,2-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000127
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(1,3-dimethyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone
6.4.1.2 0.000169
-
in 250 mM phosphate buffer, at 37°C, pH not specified in the publication Homo sapiens 1-(4-[[4-(4-[[2-(3-ethyl-2-methyl-2,3-dihydro-1H-indol-5-yl)-6-phenylpyridin-4-yl]carbonyl]piperazin-1-yl)piperidin-1-yl]carbonyl]piperidin-1-yl)ethanone