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Literature summary extracted from
- Inhibition of fumarase by bismuth(III): implications for the tricarboxylic acid cycle as a potential target of bismuth drugs in Helicobacter pylori (2012), Biometals, 25, 95-102.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.1.2 | gene HP1325, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3) | Helicobacter pylori |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.2.1.2 | Bi3+ | - |
Helicobacter pylori |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.2 | 50900 | - |
x * 50900, about, sequence calculation, x * 43000-45000, recombinant enzyme, SDS-PAGE | Helicobacter pylori |
| 4.2.1.2 | 440000 | - |
oligomer 1, gel filtration | Helicobacter pylori |
| 4.2.1.2 | 600000 | - |
oligomer 2, gel filtration | Helicobacter pylori |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.2 | (S)-malate | Helicobacter pylori | - |
fumarate + H2O | - |
r | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.2 | Helicobacter pylori | - |
gene HP1325 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.2 | (S)-malate | - |
Helicobacter pylori | fumarate + H2O | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.2 | ? | x * 50900, about, sequence calculation, x * 43000-45000, recombinant enzyme, SDS-PAGE | Helicobacter pylori |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.2 | fumarase | - |
Helicobacter pylori |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.2 | 25 | - |
assay at | Helicobacter pylori |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.2 | 7.6 | - |
assay at | Helicobacter pylori |
pI Value
| EC Number | Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|---|
| 4.2.1.2 | Helicobacter pylori | sequence calculation | - |
6.79 |
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Release 2023.1 (January 2023)
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