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Literature summary extracted from

  • Tsuboi, K.; Okamoto, Y.; Ikematsu, N.; Inoue, M.; Shimizu, Y.; Uyama, T.; Wang, J.; Deutsch, D.G.; Burns, M.P.; Ulloa, N.M.; Tokumura, A.; Ueda, N.
    Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways (2011), Biochim. Biophys. Acta, 1811, 565-577.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.39 recombinant expression of GDE1 in COS-7 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.54 additional information generation of NAPE-PLD-/- mice, phenotype, overview Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.39 Ca2+
-
 Mus musculus
3.1.4.39 EDTA
-
 Mus musculus
3.1.4.54 4-chloromercuribenzoic acid
-
 Mus musculus
3.1.4.54 Ca2+
-
 Mus musculus
3.1.4.54 DTT
-
 Mus musculus
3.1.4.54 EDTA
-
 Mus musculus
3.1.4.54 Triton X-100
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.39 membrane
-
 Mus musculus 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.39 Mg2+ required Mus musculus
3.1.4.54 Mg2+ activates, methyl arachidonyl fluorophosphonate inhibits activation by Mg2+ slightly Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.39 additional information Mus musculus brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview ?
-
 ?
3.1.4.39 additional information Mus musculus C57BL/6 brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview ?
-
 ?
3.1.4.54 additional information Mus musculus recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview ?
-
 ?
3.1.4.54 additional information Mus musculus C57BL/6 recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.39 Mus musculus
-
-
-
3.1.4.54 Mus musculus
-
-
-
3.1.4.54 Mus musculus C57BL/6
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.39 brain
-
 Mus musculus
-
3.1.4.54 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.39 1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Mus musculus 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
-
 ?
3.1.4.39 1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Mus musculus C57BL/6 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
-
 ?
3.1.4.39 additional information brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview Mus musculus ?
-
 ?
3.1.4.39 additional information brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview Mus musculus C57BL/6 ?
-
 ?
3.1.4.54 1,2-dioleoyl-sn-glycero-3-phospho(N-palmitoyl)ethanolamine + H2O
-
 Mus musculus 1,2-dioleoyl-sn-glycero-3-phosphate + N-palmitoyl-phosphatidylethanolamine
-
 ?
3.1.4.54 1,2-dioleoyl-sn-glycero-3-phospho(N-palmitoyl)ethanolamine + H2O
-
 Mus musculus C57BL/6 1,2-dioleoyl-sn-glycero-3-phosphate + N-palmitoyl-phosphatidylethanolamine
-
 ?
3.1.4.54 1-O-octadecenyl-2-oleoyl-sn-glycero-3-phospho(N-palmitoyl)ethanolamine + H2O
-
 Mus musculus 1-O-octadecenyl-2-oleoyl-sn-glycerol-3-phosphate + N-palmitoyl-phosphatidylethanolamine
-
 ?
3.1.4.54 additional information recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview Mus musculus ?
-
 ?
3.1.4.54 additional information substrate specificity of the brain enzyme, detailed overview Mus musculus ?
-
 ?
3.1.4.54 additional information recombinant NAPE-PLD catalyzes direct release of N-palmitoylethanolamine from N-palmitoylethanolamine plasmalogen, the reaction is also catalyzes in the brain in absence of NAPE-PLD, overview Mus musculus C57BL/6 ?
-
 ?
3.1.4.54 additional information substrate specificity of the brain enzyme, detailed overview Mus musculus C57BL/6 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.39 GDE1
-
 Mus musculus
3.1.4.39 glycerophosphodiesterase
-
 Mus musculus
3.1.4.39 lysophospholipase D
-
 Mus musculus
3.1.4.39 lysoPLD
-
 Mus musculus
3.1.4.54 NAPE-PLD
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.39 37
-
 assay at Mus musculus
3.1.4.54 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.39 7.4
-
 assay at Mus musculus
3.1.4.54 7.4
-
 assay at Mus musculus

General Information

EC Number General Information Comment Organism
3.1.4.39 physiological function GDE1 has a weak activity to generate N-palmitoylethanolamine from its corresponding 1-alkenyl-2-hydroxy-glycero-3-phospho(N-acyl)ethanolamines, suggesting that this enzyme is at least in part responsible for the lysophospholipase D activity in mouse brain Mus musculus
3.1.4.54 malfunction remarkable accumulation of 1-alkenyl-2-hydroxy-glycero-3-phospho(N-acyl)ethanolamines in the brain of NAPE-PLD-deficient mice Mus musculus
3.1.4.54 metabolism NAPE-PLD-dependent and -independent, via lysophospholipase D, N-acylphosphatidylethanolamines metabolism in the brain, overview. Brain tissue N-acylethanolamines, including anandamide, can be formed from N-acylated plasmalogen through an NAPE-PLD-independent pathway as well as by their direct release via NAPE-PLD. Mus musculus
3.1.4.54 additional information brain homogenate also form N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso pNAPEs by a Mg2+-dependent lysophospholipase D Mus musculus
3.1.4.54 physiological function NAPE-PLD is involved in formation of N-acylethanolamines, e.g. include anandamide, N-palmitoylethanolamine,, and N-oleoylethanolamine, from N-acylphosphatidylethanolamines in the brain Mus musculus