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Literature summary extracted from

  • Rodriguez, J.; Ben Ali, Y.; Abdelkafi, S.; Mendoza, L.; Leclaire, J.; Fotiadu, F.; Buono, G.; Carrière, F.; Abousalham, A.
    In vitro stereoselective hydrolysis of diacylglycerols by hormone-sensitive lipase (2010), Biochim. Biophys. Acta, 1801, 77-83.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.79 human HSL is expressed from baculovirus-infected insect cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.79 additional information Homo sapiens the enzyme a substrate preference for the diacylglycerols originating from triacylglycerols. The ee% of 1,2-sn-diolein over 2,3-sn-diolein increases with the level of hydrolysis indicated that HSL has a preference for 2,3-sn-diolein as a substrate and therefore a stereopreference for the sn-3 position of dioleoylglycerol. The ee% of 1,2-sn-diolein reaches a maximum value of 36% at 42% hydrolysis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.79 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.79 recombinant human HSL from baculovirus-infected insect cells Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.79 adipocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.79 additional information the enzyme a substrate preference for the diacylglycerols originating from triacylglycerols. The ee% of 1,2-sn-diolein over 2,3-sn-diolein increases with the level of hydrolysis indicated that HSL has a preference for 2,3-sn-diolein as a substrate and therefore a stereopreference for the sn-3 position of dioleoylglycerol. The ee% of 1,2-sn-diolein reaches a maximum value of 36% at 42% hydrolysis Homo sapiens ?
-
 ?
3.1.1.79 rac 1,2(2,3)-sn diolein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.79 HSL
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.79 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.79 8
-
 assay at Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.1.79 physiological function hormone-sensitive lipase contributes importantly to the mobilization of fatty acids in adipocytes and shows a substrate preference for the diacylglycerols originating from triacylglycerols Homo sapiens