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Literature summary extracted from

  • Reinartz, A.; Ehling, J.; Leue, A.; Liedtke, C.; Schneider, U.; Kopitz, J.; Weiss, T.; Hellerbrand, C.; Weiskirchen, R.; Knuechel, R.; Gassler, N.
    Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis (2010), Biochim. Biophys. Acta, 1801, 1025-1035.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
6.2.1.3 additional information overexpression of ACSL5 decreases HepG2 cell viability and increases susceptibility to TRAIL- and TNFalpha-, but not FAS- induced apoptosis, whereas knockdown of ACSL5 reduces apoptosis susceptibility Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.2.1.3 mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.2.1.3 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.2.1.3 ATP + hexadecanoate + CoA Homo sapiens
-
 AMP + diphosphate + hexadecanoyl-CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.2.1.3 Homo sapiens
-
 isozyme ACSL5
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.2.1.3 Hep-G2 cell
-
 Homo sapiens
-
6.2.1.3 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.2.1.3 ATP + hexadecanoate + CoA
-
 Homo sapiens AMP + diphosphate + hexadecanoyl-CoA
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.2.1.3 ACSL5
-
 Homo sapiens
6.2.1.3 acyl-CoA synthetase 5
-
 Homo sapiens
6.2.1.3 More the enzyme is a member of the ACSL gene family that catalyzes the activation of long-chain fatty acids for lipid biosynthesis Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
6.2.1.3 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.2.1.3 7.5
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.2.1.3 ATP
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
6.2.1.3 Homo sapiens lipid-induced up-regulation of acyl-CoA synthetase 5 promotes hepatocellular apoptosis. ACSL5 expression is enhanced in steatotic liver up

General Information

EC Number General Information Comment Organism
6.2.1.3 malfunction lipid-induced up-regulation of acyl-CoA synthetase 5 promotes hepatocellular apoptosis. High ACSL5 activity results in enhanced caspase-3/7 activity, but is not accompanied by up-regulation of death receptors, DR4, DR5 or TNF-R1 Homo sapiens
6.2.1.3 metabolism acyl-CoA synthetase 5 is involved in the activation of long-chain fatty acids for lipid biosynthesis, and it is the only ACSL isoform that is both, located on mitochondria and functionally involved in enterocyte apoptosis. Analysis of regulation of ACSL5 in hepatocellular fatty acid degeneration and its involvement in hepatocyte apoptosis using models of in vitro and in vivo steatosis as well as plasmid-mediated stable gene transfer and RNAi-mediated gene silencing Homo sapiens
6.2.1.3 physiological function ACSL5 plays a role in promoting fatty acid-induced lipoapoptosis in hepatocytes as important mechanism in fatty liver-related disorders Homo sapiens