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Literature summary extracted from

  • DeCorby, A.; Gaskova, D.; Sayles, L.; Lemire, B.
    Expression of Ndi1p, an alternative NADH:ubiquinone oxidoreductase, increases mitochondrial membrane potential in a C. elegans model of mitochondrial disease (2007), Biochim. Biophys. Acta, 1767, 1157-1163.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.2 medicine gene therapy approaches involving Ndi1p may offer substantial clinical benefits in cases of complex I deficiency Caenorhabditis elegans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
Caenorhabditis elegans 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.1.1.2 53000
-
SDS-PAGE Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.1.1.2 NADH + H+ + ubiquinone Caenorhabditis elegans
-
NAD+ + ubiquinol
-
?
7.1.1.2 NADH + H+ + ubiquinone Caenorhabditis elegans N2
-
NAD+ + ubiquinol
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Caenorhabditis elegans
-
-
-
7.1.1.2 Caenorhabditis elegans N2
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + H+ + ubiquinone
-
Caenorhabditis elegans NAD+ + ubiquinol
-
?
7.1.1.2 NADH + H+ + ubiquinone
-
Caenorhabditis elegans N2 NAD+ + ubiquinol
-
?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 alternative NADH:ubiquinone oxidoreductase
-
Caenorhabditis elegans
7.1.1.2 Ndi1p
-
Caenorhabditis elegans

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 FAD noncovalently bound Caenorhabditis elegans
7.1.1.2 additional information Ndi1p lacks iron sulfur clusters Caenorhabditis elegans
7.1.1.2 NADH
-
Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
7.1.1.2 physiological function Ndi1p functionally interacts with the nematode respiratory chain and contributes to the formation of the mitochondrial membrane potential in vivo. Ndi1p expression results in significantly improved reproductive success, better survival under conditions of oxidative stress, fewer signs of premature aging, increased respiration rates and a complete restoration of the in vivo mitochondrial membrane potential in Caenorhabditis elegans nuo-1 mutants. However, Ndi1p is not able to fully replace complex I and cannot support larval development when complex I is missing Caenorhabditis elegans