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Literature summary extracted from

  • Chen, M.; Jiang, M.; Sun, Y.; Guo, Z.; Guo, Z.
    Stabilization of the second oxyanion intermediate by 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase of the menaquinone pathway: Spectroscopic evidence of the involvement of a conserved aspartic acid (2011), Biochemistry, 50, 5893-5904.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.3.36
-
 Escherichia coli

Protein Variants

EC Number Protein Variants Comment Organism
4.1.3.36 D163A loss of the ligand binding ability Escherichia coli
4.1.3.36 D163E 14% 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity Escherichia coli
4.1.3.36 D163N no 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity Escherichia coli
4.1.3.36 R91A no 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity Escherichia coli
4.1.3.36 S161A expressed in inclusion bodies and unavailable for the binding test Escherichia coli
4.1.3.36 Y258F no 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity Escherichia coli
4.1.3.36 Y94F wild type level activity Escherichia coli
4.1.3.36 Y97F no 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.3.36 1-hydroxy-2-naphthoyl-CoA
-
 Escherichia coli
4.1.3.36 2,3-dihydroxybenzoyl-CoA
-
 Escherichia coli
4.1.3.36 2,4-dihydroxybenzoyl-CoA
-
 Escherichia coli
4.1.3.36 salicylyl-CoA
-
 Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.36 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.1.3.36 ammonium sulfate precipitation, ion exchange chromatography (DEAE), gel filtration Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.36 o-succinylbenzoyl-CoA
-
 Escherichia coli 1,4-dihydroxy-2-naphthoyl-CoA + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.3.36 1,4-dihydroxy-2-naphthoyl-coenzyme synthase
-
 Escherichia coli
4.1.3.36 MenB
-
 Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.3.36 0.0013
-
 1-hydroxy-2-naphthoyl-CoA pH 7,0, 23°C Escherichia coli
4.1.3.36 0.0022
-
 2,4-dihydroxybenzoyl-CoA pH 7,0, 23°C Escherichia coli
4.1.3.36 0.0031
-
 2,3-dihydroxybenzoyl-CoA pH 7,0, 23°C Escherichia coli
4.1.3.36 0.006
-
 salicylyl-CoA pH 7,0, 23°C Escherichia coli