EC Number | Cloned (Comment) | Organism |
---|---|---|
4.1.3.36 | - |
Escherichia coli |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.1.3.36 | D163A | loss of the ligand binding ability | Escherichia coli |
4.1.3.36 | D163E | 14% 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity | Escherichia coli |
4.1.3.36 | D163N | no 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity | Escherichia coli |
4.1.3.36 | R91A | no 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity | Escherichia coli |
4.1.3.36 | S161A | expressed in inclusion bodies and unavailable for the binding test | Escherichia coli |
4.1.3.36 | Y258F | no 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity | Escherichia coli |
4.1.3.36 | Y94F | wild type level activity | Escherichia coli |
4.1.3.36 | Y97F | no 1,4-dihydroxy-2-naphthoyl-CoA synthetic activity | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.3.36 | 1-hydroxy-2-naphthoyl-CoA | - |
Escherichia coli | |
4.1.3.36 | 2,3-dihydroxybenzoyl-CoA | - |
Escherichia coli | |
4.1.3.36 | 2,4-dihydroxybenzoyl-CoA | - |
Escherichia coli | |
4.1.3.36 | salicylyl-CoA | - |
Escherichia coli |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.3.36 | Escherichia coli | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.1.3.36 | ammonium sulfate precipitation, ion exchange chromatography (DEAE), gel filtration | Escherichia coli |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.3.36 | o-succinylbenzoyl-CoA | - |
Escherichia coli | 1,4-dihydroxy-2-naphthoyl-CoA + H2O | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.3.36 | 1,4-dihydroxy-2-naphthoyl-coenzyme synthase | - |
Escherichia coli |
4.1.3.36 | MenB | - |
Escherichia coli |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.3.36 | 0.0013 | - |
1-hydroxy-2-naphthoyl-CoA | pH 7,0, 23°C | Escherichia coli | |
4.1.3.36 | 0.0022 | - |
2,4-dihydroxybenzoyl-CoA | pH 7,0, 23°C | Escherichia coli | |
4.1.3.36 | 0.0031 | - |
2,3-dihydroxybenzoyl-CoA | pH 7,0, 23°C | Escherichia coli | |
4.1.3.36 | 0.006 | - |
salicylyl-CoA | pH 7,0, 23°C | Escherichia coli |