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Literature summary extracted from

  • Cotruvo, J.A.; Stubbe, J.
    Escherichia coli class Ib ribonucleotide reductase contains a dimanganese(III)-tyrosyl radical cofactor in vivo (2011), Biochemistry, 50, 1672-1681.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.4.1 Fe3+ diferric(III)-tyrosyl radical cofactor Escherichia coli
1.17.4.1 Mn3+ dimanganese(III)-tyrosyl radical cofactor Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Escherichia coli
-
 genes nrdE and nrdF encoding the subunits alpha2 and beta2
-
1.17.4.1 Escherichia coli GR536
-
 genes nrdE and nrdF encoding the subunits alpha2 and beta2
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.17.4.1 native NrdF from strain GR536 Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
1.17.4.1 class Ib ribonucleotide reductase
-
 Escherichia coli
1.17.4.1 class Ib RNR
-
 Escherichia coli
1.17.4.1 NrdE
-
 Escherichia coli
1.17.4.1 NrdF
-
 Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.17.4.1 37
-
 assay at Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.4.1 8.5
-
 assay at Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.4.1 diferric(III)-tyrosyl radical cofactor FeIII2-tyrosyl radical cofactor Escherichia coli
1.17.4.1 dimanganese(III)-tyrosyl radical cofactor MnIII2-tyrosyl radical cofactor Escherichia coli
1.17.4.1 additional information RNR is active with both FeIII2-tyrosyl radical and MnIII2-tyrosyl radical cofactors in the beta2 subunit, NrdF Escherichia coli

General Information

EC Number General Information Comment Organism
1.17.4.1 physiological function class Ib RNR converts nucleoside 5'-diphosphates to deoxynucleoside 5'-diphosphates in iron-limited and oxidative stress conditions Escherichia coli