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Literature summary extracted from

  • Goettle, M.; Dove, S.; Kees, F.; Schlossmann, J.; Geduhn, J.; Koenig, B.; Shen, Y.; Tang, W.J.; Kaever, V.; Seifert, R.
    Cytidylyl and uridylyl cyclase activity of Bacillus anthracis edema factor and Bordetella pertussis CyaA (2010), Biochemistry, 49, 5494-5503.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.6 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate
-
 Bacillus anthracis
4.6.1.6 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate
-
 Bordetella pertussis
4.6.1.6 methylanthraniloyl-ATP
-
 Bacillus anthracis
4.6.1.6 methylanthraniloyl-ATP
-
 Bordetella pertussis
4.6.1.6 methylanthraniloyl-CTP
-
 Bacillus anthracis
4.6.1.6 methylanthraniloyl-CTP
-
 Bordetella pertussis
4.6.1.6 methylanthraniloyl-GTP
-
 Bacillus anthracis
4.6.1.6 methylanthraniloyl-GTP
-
 Bordetella pertussis
4.6.1.6 methylanthraniloyl-ITP
-
 Bacillus anthracis
4.6.1.6 methylanthraniloyl-ITP
-
 Bordetella pertussis
4.6.1.6 methylanthraniloyl-UTP
-
 Bacillus anthracis
4.6.1.6 methylanthraniloyl-UTP
-
 Bordetella pertussis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.6.1.6 0.0125
-
 CTP in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 0.0686
-
 CTP in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bordetella pertussis
4.6.1.6 0.4197
-
 CTP in the presence of 5 mM Mg2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.6 Mg2+ required Bacillus anthracis
4.6.1.6 Mn2+ required Bordetella pertussis

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.6 Bacillus anthracis
-
-
-
4.6.1.6 Bordetella pertussis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.6 CTP
-
 Bordetella pertussis 3',5'-cyclic CMP + diphosphate
-
 ?
4.6.1.6 CTP
-
 Bacillus anthracis 3',5'-cyclic CMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.6 CyaA also possesses cytidylyl cyclase activity Bordetella pertussis
4.6.1.6 cytidylyl cyclase
-
 Bordetella pertussis
4.6.1.6 cytidylyl cyclase
-
 Bacillus anthracis
4.6.1.6 Edema factor also possesses cytidylyl cyclase activity Bacillus anthracis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.6.1.6 0.3
-
 CTP in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bordetella pertussis
4.6.1.6 7.2
-
 CTP in the presence of 5 mM Mg2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 8.8
-
 CTP in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.6.1.6 0.0000011
-
 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bordetella pertussis
4.6.1.6 0.0000011
-
 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 0.0000045
-
 9-[2-(phosphonomethoxy)ethyl]adenine diphosphate in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 0.00008
-
 methylanthraniloyl-CTP in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 0.00058
-
 methylanthraniloyl-ATP in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 0.001
-
 methylanthraniloyl-ITP in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bordetella pertussis
4.6.1.6 0.0013
-
 methylanthraniloyl-CTP in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bordetella pertussis
4.6.1.6 0.0018
-
 methylanthraniloyl-UTP in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bordetella pertussis
4.6.1.6 0.0028
-
 methylanthraniloyl-GTP in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 0.0038
-
 methylanthraniloyl-UTP in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 0.0044
-
 methylanthraniloyl-ATP in 75 mM HEPES-NaOH, pH 7.4,at 37°C Bordetella pertussis
4.6.1.6 0.0057
-
 methylanthraniloyl-ITP in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 0.0061
-
 methylanthraniloyl-GTP in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bordetella pertussis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
4.6.1.6 4.37
-
 CTP in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bordetella pertussis
4.6.1.6 17.2
-
 CTP in the presence of 5 mM Mg2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis
4.6.1.6 704
-
 CTP in the presence of 5 mM Mn2+, in 75 mM HEPES-NaOH, pH 7.4, at 37°C Bacillus anthracis