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Literature summary extracted from

  • Jaruga, P.; Xiao, Y.; Vartanian, V.; Lloyd, R.S.; Dizdaroglu, M.
    Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines (2010), Biochemistry, 49, 1053-1055.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.2.2.23 Mus musculus
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-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.2.23 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.2.23 DNA containing 2,6-diamino-4-hydroxy-5-formamidopyrimidine residues + H2O
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 Mus musculus DNA + 2,6-diamino-4-hydroxy-5-formamidopyrimidine
-
 ?
3.2.2.23 DNA containing 4,6-diamino-5-formamidopyrimidine residues + H2O
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 Mus musculus 4,6-diamino-5-formamidopyrimidine + DNA
-
 ?
3.2.2.23 additional information the enzyme has no specificity for DNA containing 8-hydroxyguanine residues Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.2.23 NEIL1
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 Mus musculus

General Information

EC Number General Information Comment Organism
3.2.2.23 malfunction there is significant accumulation of 2,6-diamino-4-hydroxy-5-formamidopyrimidine, (5'R)-8,5'-cyclo-2'-deoxyadenosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine in liver DNA of neil1knockout mice that are not exposed to exogenous oxidative stress Mus musculus
3.2.2.23 physiological function NEIL1 is a DNA glycosylase that is involved in the first step of base excision repair of oxidatively induced DNA damage. NEIL1 is involved in nucleotide excision repair of (5'R)-8,5'-cyclo-2'-deoxyadenosine and (5'S)-8,5'-cyclo-2'-deoxyadenosine Mus musculus