EC Number | Cloned (Comment) | Organism |
---|---|---|
4.4.1.11 | expression in Escherichia coli | Citrobacter freundii |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.4.1.11 | glycine | - |
Citrobacter freundii | |
4.4.1.11 | L-2-aminobutanoate | - |
Citrobacter freundii | |
4.4.1.11 | L-alanine | - |
Citrobacter freundii | |
4.4.1.11 | L-norleucine | - |
Citrobacter freundii | |
4.4.1.11 | L-norvaline | - |
Citrobacter freundii |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.4.1.11 | 0.7 | - |
L-methionine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 0.97 | - |
DL-homocysteine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 4 | - |
L-methionine sulfone | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 5.82 | - |
O-acetyl-DL-homoserine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 6.2 | - |
L-methionine sulfoxide | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 6.7 | - |
L-Vinylglycine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 56.5 | - |
DL-homoserine | pH 8.0, 30°C | Citrobacter freundii |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.4.1.11 | Citrobacter freundii | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
4.4.1.11 | recombinant protein | Citrobacter freundii |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
4.4.1.11 | L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate | rate determining stage of the enzymatic reaction is deamination of aminocrotonate, important contribution of the sulfur atom and methylene groups to the efficiency of binding of substrates and inhibitors | Citrobacter freundii |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.4.1.11 | DL-homocysteine + H2O | - |
Citrobacter freundii | 2-oxobutanoate + NH3 + H2S | - |
? | |
4.4.1.11 | DL-homoserine + H2O | - |
Citrobacter freundii | NH3 + 2-oxobutanoate | - |
? | |
4.4.1.11 | L-methionine + H2O | - |
Citrobacter freundii | methanethiol + NH3 + 2-oxobutanoate | - |
? | |
4.4.1.11 | L-methionine sulfone | - |
Citrobacter freundii | ? | - |
? | |
4.4.1.11 | L-methionine sulfoxide | - |
Citrobacter freundii | ? | - |
? | |
4.4.1.11 | L-vinylglycine | - |
Citrobacter freundii | ? | - |
? | |
4.4.1.11 | additional information | determination of rate constants of the enzyme-catalyzed exchange of Calpha and Cbeta-protons with deuterium, as well as the kinetic isotope effect of the deuterium label in the Calpha-position of inhibitors on the rate of exchange of their beta-protons. Neither stereoselectivity in the beta-proton exchange nor noticeable isotope effect on the exchange rates of beta-protons is found | Citrobacter freundii | ? | - |
? | |
4.4.1.11 | O-acetyl-DL-homoserine + H2O | - |
Citrobacter freundii | NH3 + 2-oxobutanoate + acetate | - |
? |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.4.1.11 | 0.52 | - |
DL-homoserine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 1.9 | - |
L-Vinylglycine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 2.1 | - |
L-methionine sulfone | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 2.1 | - |
O-acetyl-DL-homoserine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 2.5 | - |
L-methionine sulfoxide | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 6.2 | - |
L-methionine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 8.5 | - |
DL-homocysteine | pH 8.0, 30°C | Citrobacter freundii |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
4.4.1.11 | pyridoxal 5'-phosphate | - |
Citrobacter freundii |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.4.1.11 | 0.6 | - |
L-norleucine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 3.4 | - |
L-alanine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 4.7 | - |
L-norvaline | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 8.3 | - |
L-2-aminobutanoate | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 49 | - |
glycine | pH 8.0, 30°C | Citrobacter freundii |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.4.1.11 | 0.01 | - |
DL-homoserine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 0.28 | - |
L-Vinylglycine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 0.36 | - |
O-acetyl-DL-homoserine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 0.4 | - |
L-methionine sulfoxide | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 0.52 | - |
L-methionine sulfone | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 8.8 | - |
DL-homocysteine | pH 8.0, 30°C | Citrobacter freundii | |
4.4.1.11 | 8.9 | - |
L-methionine | pH 8.0, 30°C | Citrobacter freundii |