Literature summary extracted from

Valiyaveettil, M.; Alamneh, Y.; Rezk, P.; Biggemann, L.; Perkins, M.W.; Sciuto, A.M.; Doctor, B.P.; Nambiar, M.P.
Protective efficacy of catalytic bioscavenger, paraoxonase 1 against sarin and soman exposure in guinea pigs (2011), Biochem. Pharmacol., 81, 800-809.

Application

EC Number	Application	Comment	Organism
3.1.1.2	medicine	paraoxonase 1 significantly protects against sarin and soman exposure in guinea pigs and supports the development of paraoxonase 1 as a catalytic bioscavenger for protection against lethal exposure of chemical warfare nerve agents exposure	Homo sapiens
3.1.1.2	medicine	paraoxonase 1 significantly protects against sarin and soman exposure in guinea pigs and supports the development of paraoxonase 1 as a catalytic bioscavenger for protection against lethal exposure of chemical warfare nerve agents exposure	Oryctolagus cuniculus
3.1.8.1	medicine	paraoxonase 1 significantly protects against sarin and soman exposure in guinea pigs and supports the development of paraoxonase 1 as a catalytic bioscavenger for protection against lethal exposure of chemical warfare nerve agents exposure	Homo sapiens
3.1.8.1	medicine	paraoxonase 1 significantly protects against sarin and soman exposure in guinea pigs and supports the development of paraoxonase 1 as a catalytic bioscavenger for protection against lethal exposure of chemical warfare nerve agents exposure	Oryctolagus cuniculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.2	Homo sapiens	-	-	-
3.1.1.2	Oryctolagus cuniculus	-	-	-
3.1.8.1	Homo sapiens	-	-	-
3.1.8.1	Oryctolagus cuniculus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
3.1.1.2	-	Homo sapiens
3.1.1.2	-	Oryctolagus cuniculus
3.1.8.1	-	Homo sapiens
3.1.8.1	-	Oryctolagus cuniculus

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.1.2	serum	-	Homo sapiens	-
3.1.1.2	serum	-	Oryctolagus cuniculus	-
3.1.8.1	serum	-	Homo sapiens	-
3.1.8.1	serum	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.1.2	4-nitrophenyl acetate + H2O	-	Homo sapiens	4-nitrophenol + acetate	-	?
3.1.1.2	4-nitrophenyl acetate + H2O	-	Oryctolagus cuniculus	4-nitrophenol + acetate	-	?
3.1.1.2	phenyl acetate + H2O	-	Homo sapiens	phenol + acetate	-	?
3.1.1.2	phenyl acetate + H2O	-	Oryctolagus cuniculus	phenol + acetate	-	?
3.1.8.1	paraoxon + H2O	-	Homo sapiens	4-nitrophenol + diethyl phosphate	-	?
3.1.8.1	paraoxon + H2O	-	Oryctolagus cuniculus	4-nitrophenol + diethyl phosphate	-	?
3.1.8.1	sarin + H2O	-	Homo sapiens	?	-	?
3.1.8.1	sarin + H2O	-	Oryctolagus cuniculus	?	-	?
3.1.8.1	soman + H2O	-	Homo sapiens	?	-	?
3.1.8.1	soman + H2O	-	Oryctolagus cuniculus	?	-	?

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Release 2023.1 (January 2023)