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Literature summary extracted from

  • Cunningham, O.; Gore, M.G.; Mantle, T.J.
    Initial-rate kinetics of the flavin reductase reaction catalysed by human biliverdin-IXbeta reductase (BVR-B) (2000), Biochem. J., 345, 393-399.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.30 lumichrome competitive inhibitor against FMN and a mixed inhibitor of NADPH Homo sapiens
1.5.1.30 mesobiliverdin XIIIa competitive kinetics with FMN and mixed inhibition kinetics with NADPH Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.30 0.052
-
 FMN pH 7.5, 25°C Homo sapiens
1.5.1.30 0.053
-
 oxidized riboflavin pH 7.5, 25°C Homo sapiens
1.5.1.30 0.125
-
 FAD pH 7.5, 25°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.30 Homo sapiens P30043 bifunctional enzyme biliverdin reductase/flavin reductase (NADPH)
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.30 FAD + NADPH + H+
-
 Homo sapiens FADH2 + NADP+
-
 ?
1.5.1.30 FMN + NADPH + H+
-
 Homo sapiens FMNH2 + NADP+
-
 ?
1.5.1.30 oxidized riboflavin + NADPH + H+
-
 Homo sapiens reduced riboflavin + NADP+
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.1.30 25
-
 assay at Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.5.1.30 0.099
-
 FMN pH 7.5, 25°C Homo sapiens
1.5.1.30 0.3
-
 FAD pH 7.5, 25°C Homo sapiens
1.5.1.30 0.3
-
 oxidized riboflavin pH 7.5, 25°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.30 5
-
 sharp optimum, in citrate buffer Homo sapiens
1.5.1.30 7.5
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.5.1.30 0.00059
-
 mesobiliverdin XIIIa pH 7.5, 25°C Homo sapiens
1.5.1.30 0.076
-
 lumichrome pH 7.5, 25°C Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.5.1.30 1.9
-
 FMN pH 7.5, 25°C Homo sapiens
1.5.1.30 2.4
-
 FAD pH 7.5, 25°C Homo sapiens
1.5.1.30 5.6
-
 oxidized riboflavin pH 7.5, 25°C Homo sapiens