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Literature summary extracted from

  • Ohta, K.; Sekiya, M.; Uozaki, H.; Igarashi, M.; Takase, S.; Kumagai, M.; Takanashi, M.; Takeuchi, Y.; Izumida, Y.; Kubota, M.; Nishi, M.; Okazaki, H.; Iizuka, Y.; Yahagi, N.; Yagyu, H.; Fukayama, M.; Kadowaki, T.; Ohashi, K.; Ishibashi, S.; Osuga, J.
    Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement (2011), Biochem. Biophys. Res. Commun., 404, 254-260.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.13 cytosol
-
 Mus musculus 5829
-
3.1.1.13 microsome
-
 Mus musculus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 adrenal gland
-
 Mus musculus
-
3.1.1.13 brain
-
 Mus musculus
-
3.1.1.13 heart
-
 Mus musculus
-
3.1.1.13 kidney
-
 Mus musculus
-
3.1.1.13 liver
-
 Mus musculus
-
3.1.1.13 white adipose tissue
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl oleate + H2O
-
 Mus musculus cholesterol + oleate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 Nceh1
-
 Mus musculus
3.1.1.13 neutral cholesterol ester hydrolase 1
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.1.1.13 malfunction hormone-sensitive lipase deficiency remarkably reduces the neutral cholesterol ester hydrolase activity in adrenal glands. Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement Mus musculus
3.1.1.13 physiological function Nceh1 is involved in the adrenal cholesterol metabolism, and the cholesterol ester hydrolytic activity in adrenal glands is associated with the organ enlargement Mus musculus